MCP-1 −2518 A/G functional polymorphism is associated with increased susceptibility to active pulmonary tuberculosis in Tunisian patients

Ben-Selma, Walid; Harizi, Hedi; Boukadida, Jalel

doi:10.1007/s11033-011-0695-4

Cited by 30 publications

(24 citation statements)

References 47 publications

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“…The results of the study are consistent with those of previous reports regarding the association between MCP-1 -2518A/G polymorphisms and tuberculosis in Mexicans, Koreans, Peruvians, Tunisians, and Zambians (Flores-Villanueva et al, 2005;Buijtels et al, 2008;Ganachari et al, 2010;Ben-Selma et al, 2011). Others have reported different results, such as in South African Coloreds, Indians, and Ghanaians (Alagarasu et al, 2009;Moller et al, 2009;Thye et al, 2009).…”

Section: Discussionsupporting

confidence: 91%

“…Thus, further studies are needed to assess the effect of additional interactions in different ethnicities and to validate our results. The molecular mechanism of the association between the MCP-1 gene and PTB may be that the MCP-1 is a potent chemotactic factor for monocytes (Flores-Villanueva et al, 2005;Ben-Selma et al, 2011), which plays critical roles in the recruitment of macrophages and T lymphocytes for controlling the dissemination of Mycobacterium TB (Xu et al, 2009). The -2518A/G polymorphism in the MCP-1 regulatory region influences the levels of MCP-1 expression in response to inflammatory stimuli.…”

Section: Discussionmentioning

confidence: 99%

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MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Shi¹,

Yang²,

Sun³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations. To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis. Polymerase chain reaction amplification of genomic DNA followed by restriction fragment length polymorphism analysis was used. There was a significant increase in the frequency of the GG genotype of MCP-1 -2518 in 136 patients with PTB compared to that in 152 healthy controls (P = 0.008, c 2 = 7.133, odds ratio = 1.96). Similarly, the frequencies of the A/G alleles in the 2 groups differed; the frequency of allele G was higher in patients with PTB (P = 0.011, c 2 = 6.428, odds ratio = 1.536). In conclusion, the -2518A/G polymorphism in the MCP-1 gene G.L. Shi et al. 4036©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4035-4040 (2015) was found to be associated with an increased susceptibility to PTB in a North Chinese population.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Shi¹,

Yang²,

Sun³

et al. 2015

Genet. Mol. Res.

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“…However, the concentration of G-CSF needs to be optimized to make sure that the dose of G-CSF does not induce PMN-induced acute lung injury and possibly, ARDS. It has also been demonstrated that MCP-1 polymorphism is associated with increased susceptibility to Mycobacterium tuberculosis infection (81, 82) and bacterial peritonitis (83). …”

Section: Discussionmentioning

confidence: 99%

Intrapulmonary G-CSF Rescues Neutrophil Recruitment to the Lung and Neutrophil Release to Blood in Gram-Negative Bacterial Infection in MCP-1−/− Mice

Balamayooran

Batra

Theivanthiran

et al. 2012

The Journal of Immunology

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We previously demonstrated that MCP-1 is important for E. coli-induced neutrophil migration to the lungs. However, E. coli neither disseminates nor induces death in mice. Furthermore, the cell types and the host defense mechanisms which contribute to MCP-1-dependent neutrophil trafficking have not been defined. In this study, we sought to explore the cell types and the mechanisms associated with K. pneumoniae-mediated MCP-1-dependent neutrophil influx. MCP-1−/− mice are more susceptible to pulmonary K. pneumoniae infection and show higher bacterial burden in the lungs and dissemination. MCP-1−/− mice also display attenuated neutrophil influx, cytokine/chemokine production and activation of NF-κB and MAPKs following intratracheal (i.t) K. pneumoniae infection. Recombinant MCP-1 (rMCP-1) treatment in MCP-1−/− mice following K. pneumoniae infection rescued impairment in survival, bacterial clearance and neutrophil accumulation in the lung. Neutrophil numbers in the blood of MCP-1−/− mice were associated with G-CSF concentrations in BALF and blood. Bone marrow or resident cell-derived MCP-1 contributed to bacterial clearance, neutrophil accumulation, and cytokine/chemokine production in the lungs following infection. Furthermore, exogenous MCP-1 dose dependently increased neutrophil counts and G-CSF concentrations in the blood. Intriguingly, administration of i.t. rG-CSF to MCP-1−/− mice after K. pneumoniae infection rescued survival, bacterial clearance and dissemination, and neutrophil influx in MCP-1−/− mice. Collectively, these novel findings a) hitherto unveil an unrecognized role of MCP-1 in neutrophil mediated host immunity during K. pneumoniae pneumonia; and b) illustrate that G-CSF could be used to rescue impairment in host immunity in individuals with lacking or malfunctional MCP-1.

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“…The migration of these cells is orchestrated by chemokines and their receptors. In this context, one member of the C‐C chemokine family, namely monocyte chemoattractant protein‐1 (MCP‐1), also referred to as CCL2 (the chemokine (C‐C motif) ligand 2), is considered to be a potent chemotactic factor for monocytes (Ben‐Selma, Harizi, & Boukadida, ; Flores‐Villanueva et al., ). Human MCP‐1, which is composed of 76 amino acids and has a size of 13 kDa, plays an essential role in the innate immune response against microbial infection (Deshmane, Kremlev, Amini, & Sawaya, ; Serbina, Jia, Hohl, & Pamer, ; Van Coillie, Van Damme, & Opdenakker, ).…”

Section: Candidate Genes and The Risk Of Developing Tbmentioning

confidence: 99%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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MCP-1 −2518 A/G functional polymorphism is associated with increased susceptibility to active pulmonary tuberculosis in Tunisian patients

Cited by 30 publications

References 47 publications

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Intrapulmonary G-CSF Rescues Neutrophil Recruitment to the Lung and Neutrophil Release to Blood in Gram-Negative Bacterial Infection in MCP-1−/− Mice

Current immunogenetic predisposition to tuberculosis in the Moroccan population

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