MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models

Liu, Jianwei; Huang, Yiran; Zhu, Shuchai; Yang, Gang; Zhang, Yu-Jian; Leng, Jinhua; Jiang, Bo; Liu, Dongming

doi:10.1155/2012/358184

Cited by 37 publications

(36 citation statements)

References 22 publications

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“…Increased histidine level leads to increase of histamine level in blood, brain and possibly bladder, suggesting the possibility that histidine may have many other possible functions affecting human bladder sensory system. Previous work using IC rat model demonstrated that overexpression of monocyte chemo-attractant protein-1 (MCP-1) in bladder tissues contributes histamine production and IC12. More recently, findings from animal model suggest that mast cell-derived histamine mediates IC-associated pain.…”

Section: Discussionmentioning

confidence: 99%

Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

Kind

Cho

Park³

et al. 2016

Sci Rep

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This study on interstitial cystitis (IC) aims to identify a unique urine metabolomic profile associated with IC, which can be defined as an unpleasant sensation including pain and discomfort related to the urinary bladder, without infection or other identifiable causes. Although the burden of IC on the American public is immense in both human and financial terms, there is no clear diagnostic test for IC, but rather it is a disease of exclusion. Very little is known about the clinically useful urinary biomarkers of IC, which are desperately needed. Untargeted comprehensive metabolomic profiling was performed using gas-chromatography/mass-spectrometry to compare urine specimens of IC patients or health donors. The study profiled 200 known and 290 unknown metabolites. The majority of the thirty significantly changed metabolites before false discovery rate correction were unknown compounds. Partial least square discriminant analysis clearly separated IC patients from controls. The high number of unknown compounds hinders useful biological interpretation of such predictive models. Given that urine analyses have great potential to be adapted in clinical practice, research has to be focused on the identification of unknown compounds to uncover important clues about underlying disease mechanisms.

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Section: Discussionmentioning

confidence: 99%

Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

Kind

Cho

Park³

et al. 2016

Sci Rep

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“…Chemotactic cytokines, chemokine ligands 2 and 3 (CCL2 and CCL3), have been identified as important mediators in pelvic pain associated with a murine model of experimental prostatitis [44]. CCL2 can also induce histamine release that is subsequently associated with the development of cystitis-related pain in rats [45]. …”

Section: Mast Cells In Pre-clinical Models Of Inflammatory and Chrmentioning

confidence: 99%

Mast cells: Versatile gatekeepers of pain

Chatterjea¹,

Martinov²

2015

Molecular Immunology

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Mast cells are important first responders in protective pain responses that provoke withdrawal from intense, noxious environmental stimuli, in part because of their sentinel location in tissue-environment interfaces. In chronic pain disorders, the proximity of mast cells to nerves potentiates critical molecular cross-talk between these two cell types that results in their synergistic contribution to the initiation and propagation of long-term changes in pain responses via intricate signal networks of neurotransmitters, cytokines and adhesion molecules. Both in rodent models of inflammatory pain and chronic pain disorders, as well as in increasing evidence from the clinic, it is abundantly clear that understanding the mast cell-mediated mechanisms underlying protective and maladaptive pain cascades will lead to improved understanding of mast cell biology as well as the development of novel, targeted therapies for the treatment and management of debilitating pain conditions.

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“…References BPS/interstitial cystitis Alteration related to mast cells Increase of mast cell density in urinary bladder -detrusor muscle, submucous layer of bladder, urinary bladder epithelium [20][21][22][23][24][25] 60% increase of histamine tissue level in bioptic tissues of human bladder versus control tissue [20,21] Increase of urinary mast cell markers (histamine, methylhistamine, tryptase, NGF, IL-6, IL-8, YKL-40, etc.) [25][26][27][28][29] Alteration of nerve terminals Increase in nerve fiber density as evaluated by SP and TRPV1 immunohistochemical assessment and increased mRNANK1 receptor expression [22] IBS Alteration related to mast cells Increase of mast cell density in bioptic intestinal tissues [30][31][32][33] Increase of histamine, NGF, tryptase levels measured in bioptic tissues of human colon [31][32][33][34] Alteration of nerve terminals Increased nerve fiber density as evaluated by SP and TRPV1 immunohistochemical assessment.…”

Section: Resultsmentioning

confidence: 99%

“…[25][26][27][28][29] Alteration of nerve terminals Increase in nerve fiber density as evaluated by SP and TRPV1 immunohistochemical assessment and increased mRNANK1 receptor expression [22] IBS Alteration related to mast cells Increase of mast cell density in bioptic intestinal tissues [30][31][32][33] Increase of histamine, NGF, tryptase levels measured in bioptic tissues of human colon [31][32][33][34] Alteration of nerve terminals Increased nerve fiber density as evaluated by SP and TRPV1 immunohistochemical assessment.…”

Section: Resultsmentioning

confidence: 99%

“…An accumulation of MCs has been reported in the detrusor, lamina propria, and submucosa of patients with interstitial cystitis [20][21][22][23][24]. Moreover, increased expression of MCP-1 in bladder tissue and its receptor on MC surfaces along with elevated MCP-1 and histamine levels in the urine were observed in the bladder pain syndrome/interstitial cystitis model [25]. Elevated MC mediators, including histamine [26], tryptase [27], IL-6 [28], IL-8 [28] and NGF [29] have also been found in patients with interstitial cystitis.…”

Section: Mcs and Chronic Inflammationmentioning

confidence: 99%

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Mast cells in chronic inflammation, pelvic pain and depression in women

Graziottin

Skaper

Fusco³

2014

Gynecological Endocrinology

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Inflammatory and neuroinflammatory processes are increasingly recognized as critical pathophysiologic steps in the development of multiple chronic diseases and in the etiology of persistent pain and depression. Mast cells are immune cells now viewed as cellular sensors in inflammation and immunity. When stimulated, mast cells release an array of mediators to orchestrate an inflammatory response. These mediators can directly initiate tissue responses on resident cells, and may also regulate the activity of other immune cells, including central microglia. New evidence supports the involvement of peripheral and central mast cells in the development of pain processes as well as in the transition from acute, to chronic and neuropathic pain. That behavioral and endocrine states can increase the number and activation of peripheral and brain mast cells suggests that mast cells represent the immune cells that peripherally and centrally coordinate inflammatory processes in neuropsychiatric diseases such as depression and anxiety which are associated with chronic pelvic pain. Given that increasing evidence supports the activated mast cell as a director of common inflammatory pathways/mechanisms contributing to chronic and neuropathic pelvic pain and comorbid neuropsychiatric diseases, mast cells may be considered a viable target for the multifactorial management of both pain and depression.

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MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models

Cited by 37 publications

References 22 publications

Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

Mast cells: Versatile gatekeepers of pain

Mast cells in chronic inflammation, pelvic pain and depression in women

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