MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species

Morimoto, Hajime; Hirose, Masao; Takahashi, Masafumi; Kawaguchi, Masanori; Ise, Hirohiko; Kolattukudy, Pappachan E.; Yamada, Mitsuhiko; Ikeda, Uichi

doi:10.1093/cvr/cvn035

Cited by 69 publications

(40 citation statements)

References 33 publications

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“…53 Additionally, neutralization of MCP-1/CCL2 activity in a lipopolysaccharide model of inflammation resulted not only in decreased monocytes accumulation within the intestinal muscularis, but polymorphonuclear leukocytes infiltration was also significantly reduced. 54 ROS produced by ischemia/reperfusion injury significantly increased the mRNA expression of MCP-1/CCL2 in the heart, 55 as has also been shown for the hepatotoxin carbon tetrachloride, 56 as well as whole lung irradiation in mice. 57 IL-8/CXCL8 has been considered to be of crucial importance for recruitment of granulocytes in different tissues.…”

Section: Discussionsupporting

confidence: 57%

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Malik

Moriconi

Sheikh

et al. 2010

The American Journal of Pathology

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Liver damage is a serious clinical complication of ␥-irradiation. We therefore exposed rats to singledose ␥-irradiation (25 Gy) that was focused on the liver. Three to six hours after irradiation, an increased number of neutrophils (but not mononuclear phagocytes) was observed by immunohistochemistry to be attached to portal vessels between and around the portal (myo)fibroblasts (smooth muscle actin and Thy-1 ؉ cells). MCP-1/CCL2 staining was also detected in the portal vessel walls , including some cells of the portal area. CC-chemokine (MCP-1/CCL2 and MCP-3/CCL7) and CXC-chemokine (KC/CXCL1, MIP-2/CXCL2, and LIX/CXCL5) gene expression was significantly induced in total RNA from irradiated livers. In laser capture microdissected samples, an early (1 to 3 hours) up-regulation of CCL2, CXCL1, CXCL8, and CXCR2 gene expression was detected in the portal area but not in the parenchyma; with the exception of CXCL1 gene expression. In addition, treatment with an antibody against MCP-1/CCL2 before irradiation led to an increase in gene expression of interferon-␥ and IP-10/CXCL10 in liver tissue without influencing the recruitment of granulocytes. Indeed, the CCL2, CXCL1, CXCL2, and CXCL5 genes were strongly expressed and further up-regulated in liver (myo)fibroblasts after irradiation (8 Gy). Taken together, these results suggest that ␥-irradiation of the liver induces a transient accumulation of granulocytes within the portal area and that (myo)fibroblasts of the portal vessels may be one of the major sources of the chemokines involved in neutrophil recruitment. Moreover, inhibition of more than one chemokine (eg, CXCL1 and CXCL8) may be necessary to reduce leukocytes recruitment.

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Section: Discussionsupporting

confidence: 57%

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Malik

Moriconi

Sheikh

et al. 2010

The American Journal of Pathology

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“…Increased expression of IL-8, MCP-1, and MIP-1␣ was previously described in HZfed human placental macrophages and peripheral blood monocytes (60); additionally, HZ-laden murine bone marrow and peritoneal macrophages showed enhanced expression of MCP-1, MIP-1␣, and MIP-1␤ (23,60). Recently, both MCP-1 and IL-8 have been related to prevention of apoptosis through activation of the NF-B transcription system (12,34,62). Additionally, GRO␣ and IL-8 are powerful triggers for firm adhesion of monocytes to the vascular endothelium, revealing an unexpected role for these chemokines in monocyte recruitment (14,21).…”

Section: Discussionmentioning

confidence: 99%

Involvement of Inflammatory Chemokines in Survival of Human Monocytes Fed with Malarial Pigment

et al. 2010

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“…The protective effect of picroside II against hypoxia/ reoxygenation injury in neonatal rat cardiomyocytes injury (Morimoto et al, 2008;Zhang et al, 2011;Shen et al, 2011).…”

Section: Research Articlementioning

confidence: 99%

The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes

Meng

Hou

Yang

et al. 2012

Pharmaceutical Biology

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MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species

Abstract: These findings suggest that cardiac MCP-1 prevented LV dysfunction after global I/R through a reactive oxygen species-dependent but K(ATP) channel-independent pathway; this provides new insight into the beneficial role of MCP-1 in the pathophysiology of ischaemic heart diseases.

Cited by 69 publications

References 33 publications

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Involvement of Inflammatory Chemokines in Survival of Human Monocytes Fed with Malarial Pigment

The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes

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