MCP-1 promoter polymorphism in spanish patients with rheumatoid arthritis

Association of novel single nucleotide polymorphisms of the CXCR1 gene with the milk performance traits of Chinese native cattle

“…For example, the protein and mRNA expression of interleukin-8 have been associated with bovine mastitis (Lee et al, 2006). The effect of allelic substitution on the CCR2 rs41257559:C>T SNP on SCS is significant (Leyva-Baca et al, 2008), and CCL2 polymorphisms have been associated with increased risk of rheumatoid arthritis (Gonzalez-Escribano et al, 2003), acute pancreatitis (Papachristou et al, 2005), and myocardial infarction in humans (Dewald et al, 2005;McDermott et al, 2005). Analysis of bovine CXCR1 SNPs may contribute to the discovery of mastitis resistance-related genetic traits, because bacteria are the most common cause of mastitis in cattle.…”

CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.

“…[20][21][22][23][24][25][26][27][28] However, to our knowledge, there are no references in the literature about the role of CTLA-4 variants in alloimmunity. This study is therefore the first to show that SNPs at CTLA-4 are predictors of allogeneic transplantation outcome.…”

“…Certain polymorphisms in the CTLA-4 gene correlate with different autoimmune disorders and with some malignancies. [20][21][22][23][24][25][26] The thymine-to-cytosine nucleotide transitions at positions Ϫ1722 and Ϫ318, and the adenine-to-guanine changes at Ϫ1661,ϩ49, and CT60 have been widely investigated. Many studies have identified cytosine and adenine alleles as protective, whereas thymine and guanine are considered risk-associated or susceptibility alleles for several autoimmune diseases.…”

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

“…MCP-1-2518 A/G polymorphism is associated with the susceptibility to RA in patients lacking the specific HLA epitope, which is the risk factor for RA acquiring 25 . When patients were not stratified according to the HLA status, distribution of MCP-1-2518 A/G polymorphism was similar in patients and healthy controls 26 .…”