mcRigor: a statistical method to enhance the rigor of metacell partitioning in single-cell data analysis
Pan Liu,
Jingyi Jessica Li
Abstract:In single-cell data analysis, addressing sparsity often involves aggregating the profiles of homogeneous single cells into metacells. However, existing metacell partitioning methods lack checks on the homogeneity assumption and may aggregate heterogeneous single cells, potentially biasing down- stream analysis and leading to spurious discoveries. To fill this gap, we introduce mcRigor, a statistical method to detect dubious metacells, which are composed of heterogeneous single cells, and optimize the hyperpara… Show more
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