MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells

Pan, Huaqin; Zhang, Guqin; Zhang, Lin; Wang, Wei; Shang, Jian; Wang, Xiaobing; Zhao, Qiu; Li, Jin

doi:10.1016/j.molimm.2016.05.008

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…Currently, some controversy exists regarding the cross-talk between these pathways. One study has shown that MEK activation causes phosphorylation of NF-κB and activation of the NF-κB pathway in osteoclasts 45 . However, another study has reported that the MEK-1/ERK inhibitor PD98059 does not affect antiphospholipid antibody-induced NF-κB binding activity 46 .…”

Section: Discussionmentioning

confidence: 99%

Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling

Xiong

Liu

Yang

et al. 2017

Sci Rep

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Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. Previous studies showed that MD-1 may be restricted in the immune system. In this study, we demonstrated for the first time that MD-1 was highly expressed in both human and animal hearts. We also discovered that cardiac-specific overexpression of MD-1 significantly attenuated pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction, whereas loss of MD-1 had the opposite effects. Similar results were observed for in vitro angiotensin II-induced neonatal rat cardiomyocyte hypertrophy. The antihypertrophic effects of MD-1 under hypertrophic stimuli were associated with the blockage of MEK-ERK 1/2 and NF-κB signalling. Blocking MEK-ERK 1/2 signalling with a pharmacological inhibitor (U0126) greatly attenuated the detrimental effects observed in MD-1 knockout cardiomyocytes exposed to angiotensin II stimuli. Similar results were observed by blocking NF-κB signalling with a pharmacological inhibitor (BAY11–7082). Our data indicate that MD-1 inhibits cardiac hypertrophy and suppresses cardiac dysfunction during the remodelling process, which is dependent on its modulation of the MEK-ERK 1/2 and NF-κB signalling pathways. Thus, MD-1 might be a novel target for the treatment of pathological cardiac hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling

Xiong

Liu

Yang

et al. 2017

Sci Rep

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“…CD1A which is expressed by B cells in pigs and humans, but also by pig and human dendritic cells [69] and monocytes [70,71] is involved in lipid antigen presentation to T cells [72]. LY86, a positive regulator of signaling in response to LPS [73], is expressed in B cells and monocytes [74]. This gene expression pattern suggests that B cell number/function was positively affected by an FV-supplemented diet.…”

Section: Discussionmentioning

confidence: 99%

Fruit and Vegetable Supplemented Diet Modulates the Pig Transcriptome and Microbiome after a Two-Week Feeding Intervention

et al. 2021

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A study was conducted to determine the effects of a diet supplemented with fruits and vegetables (FV) on the host whole blood cell (WBC) transcriptome and the composition and function of the intestinal microbiome. Nine six-week-old pigs were fed a pig grower diet alone or supplemented with lyophilized FV equivalent to half the daily recommended amount prescribed for humans by the Dietary Guideline for Americans (DGA) for two weeks. Host transcriptome changes in the WBC were evaluated by RNA sequencing. Isolated DNA from the fecal microbiome was used for 16S rDNA taxonomic analysis and prediction of metabolomic function. Feeding an FV-supplemented diet to pigs induced differential expression of several genes associated with an increase in B-cell development and differentiation and the regulation of cellular movement, inflammatory response, and cell-to-cell signaling. Linear discriminant analysis effect size (LEfSe) in fecal microbiome samples showed differential increases in genera from Lachnospiraceae and Ruminococcaceae families within the order Clostridiales and Erysipelotrichaceae family with a predicted reduction in rgpE-glucosyltransferase protein associated with lipopolysaccharide biosynthesis in pigs fed the FV-supplemented diet. These results suggest that feeding an FV-supplemented diet for two weeks modulated markers of cellular inflammatory and immune function in the WBC transcriptome and the composition of the intestinal microbiome by increasing the abundance of bacterial taxa that have been associated with improved intestinal health.

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“…32,33 MD1 was found to be expressed in dendritic cells, and the loss of MD1 could weaken dextran sodium sulphate (DSS)-induced colitis by modulating the function of colonic lamina propria dendritic cells. 34 Furthermore, MD1 is also expressed in macrophages and exerts a regulatory role in lupus-prone MRL mice. 35 In our previous research, we found that MD1 is expressed in cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Initial experiments showed that MD1 was predominantly expressed in the innate immune system 32,33 . MD1 was found to be expressed in dendritic cells, and the loss of MD1 could weaken dextran sodium sulphate (DSS)‐induced colitis by modulating the function of colonic lamina propria dendritic cells 34 . Furthermore, MD1 is also expressed in macrophages and exerts a regulatory role in lupus‐prone MRL mice 35 .…”

Section: Discussionmentioning

confidence: 99%

MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway

Yang

Kong

Shuai

et al. 2020

J Cellular Molecular Medi

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MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells

Cited by 14 publications

References 32 publications

Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling

Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling

Fruit and Vegetable Supplemented Diet Modulates the Pig Transcriptome and Microbiome after a Two-Week Feeding Intervention

MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway

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