MDM-2 Overexpression in Human Stem-Like and Mature Colon Cancer Cells as a Target for Anti-Cancer Therapy: Steps toward a Translational Model

Abstract

stent placement/EndoVAC) (n¼21, 51.2%), stent placement with surgical revision (n¼10, 24.4%), or surgery alone (n¼10, 24.4%). Anastomotic leak did not affect 30-day mortality (7% AL vs 4% no AL, p¼0.2) and the treatment strategy for AL did not influence OS (p¼0.108) or DFS (p¼0.331). After a median follow-up of 35 months, OS and DFS were 101 and 93 months, respectively. On multivariate analysis, diminished OS was associated with AL (p¼0.001), high American Society of Anesthesiologists (ASA) status (p<0.0001), advanced International Union Against Cancer (UICC) stage (p<0.0001), and G3 carcinoma (p¼0.040); reduced DFS with AL (p¼0.037), advanced UICC stage (p<0.0001), G3 carcinoma (p¼0.044), and lymphangiosis carcinomatosa (p¼0.004).