1996
DOI: 10.3892/ijo.8.5.895
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MDM2 overexpression in benign and malignant lesions of the human breast

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Cited by 15 publications
(18 citation statements)
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“…MDM2 is frequently overexpressed in human breast cancer cells, [22][23][24][25] and ER-positive breast cancer cell lines express relatively high levels of mdm2 mRNA and protein compared to ER-negative cells. 26) These findings strongly suggest the biological significance of MDM2 in ER-positive breast cancer.…”
Section: Discussionmentioning
confidence: 99%
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“…MDM2 is frequently overexpressed in human breast cancer cells, [22][23][24][25] and ER-positive breast cancer cell lines express relatively high levels of mdm2 mRNA and protein compared to ER-negative cells. 26) These findings strongly suggest the biological significance of MDM2 in ER-positive breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…3,19) Although mdm2 gene amplification is uncommon in breast cancers, as in other epithelial tumors, 20,21) the level of its mRNA and/or protein is upregulated in about 40% of breast cancer specimens. [22][23][24][25] Interestingly, there was a significant positive correlation between the levels of MDM2 and estrogen receptor (ER) in breast cancer specimen and breast cancer cell lines. …”
mentioning
confidence: 99%
“…The relationship between aberration of Tp53 and MDM2 expression has been reported in several human cancers [2,9,10,24,25,27,41,42,43,45,46,52]. For example, MDM2 overexpression was detected in 50% of patients with human breast cancer and showed a significant correlation with Tp53 overexpression and shortened patient survival [11].…”
Section: Introductionmentioning
confidence: 96%
“…In addition to ER␣, the expression level of MDM2 protein is up-regulated in approxi-mately 40% of breast cancer specimens, though gene amplification of MDM2 in breast cancer is uncommon (2,3). Interestingly, there is a significant correlation between the levels of MDM2 and ER␣ in breast cancer specimens and breast cancer cell lines (25)(26)(27)(28). In contrast to ER␣-negative breast cancer cell lines, all ER␣-positive cell lines are found to express an elevated level of mdm2 mRNA (26), suggesting some functional relationship between MDM2 and ER␣.…”
mentioning
confidence: 95%