MDSCs promote pathological angiogenesis in ocular neovascular disease

Wu, Xiaojun; Zhong, Limei; Yu, Jun; Wang, Ning; Bu, Shimiao; Wang, Huijuan; Zhang, Jie; Luo, Xianqiong; Liu, Yufeng; Nie, Chuan

doi:10.1016/j.biopha.2024.117222

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117222

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MDSCs promote pathological angiogenesis in ocular neovascular disease

Xiaojun Wu,

Limei Zhong,

Jun Yu

et al.

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Cited by 1 publication

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Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Ghemiș,

Goriuc,

Minea

et al. 2024

Diagnostics

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Type 2 diabetes mellitus is a complex metabolic disorder characterized by insulin resistance and, subsequently, decreased insulin secretion. This condition is closely linked to obesity, a major risk factor that boosts the development of chronic systemic inflammation, which, in turn, is recognized for its crucial role in the onset of insulin resistance. Under conditions of obesity, adipose tissue, particularly visceral fat, becomes an active endocrine organ that releases a wide range of pro-inflammatory mediators, including cytokines, chemokines, and adipokines. These mediators, along with cluster of differentiation (CD) markers, contribute to the maintenance of systemic low-grade inflammation, promote cellular signaling and facilitate the infiltration of inflammatory cells into tissues. Emerging studies have indicated the accumulation of a new cell population in the adipose tissue in these conditions, known as myeloid-derived suppressor cells (MDSCs). These cells possess the ability to suppress the immune system, impacting obesity-related chronic inflammation. Given the limited literature addressing the role of MDSCs in the context of type 2 diabetes, this article aims to explore the complex interaction between inflammation, obesity, and MDSC activity. Identifying and understanding the role of these immature cells is essential not only for improving the management of type 2 diabetes but also for the potential development of targeted therapeutic strategies aimed at both glycemic control and the reduction in associated inflammation.

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Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Ghemiș,

Goriuc,

Minea

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

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MDSCs promote pathological angiogenesis in ocular neovascular disease

Cited by 1 publication

References 40 publications

Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

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