We study the mean curvature flow of a complete space-like submanifold in pseudo-Euclidean space with bounded Gauss image and bounded curvature. We establish a relevant maximum principle for our setting. Then, we can obtain the "confinable property" of the Gauss images and curvature estimates under the mean curvature flow. Thus we prove a corresponding long time existence result.Mathematics Subject Classification (2010). Primary 53C44.