Mean platelet volume and coronary artery disease

Pafili, Kalliopi; Penlioglou, Theano; Mikhailidis, Dimitri P.; Παπάνας, Νικόλαος

doi:10.1097/hco.0000000000000624

Cited by 44 publications

(30 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A cohort study found platelet count was positively associated with CVD risk and mortality [ 45 ], as did an MR study [ 46 ]. Few RCTs have examined these questions, but MPV is increasingly realized to be important to CVD [ 47 , 48 ], and platelet crit may be associated with stroke [ 49 ], so these may be additional mechanisms by which protective effects of statins are actuated.…”

Section: Discussionmentioning

confidence: 99%

A phenome-wide association study of genetically mimicked statins

Schooling

2021

BMC Med

View full text Add to dashboard Cite

Background Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically mimicked statins across the phenotype sex-specifically. We also assessed whether any apparently non-lipid effects identified extended to genetically mimicking other widely used lipid modifiers (proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) or were a consequence of low-density lipoprotein cholesterol (LDL-c). Methods We performed a sex-specific phenome-wide association study assessing the association of genetic variants in HMGCR, mimicking statins, with 1701 phenotypes. We used Mendelian randomization (MR) to assess if any non-lipid effects found were evident for genetically mimicked PCSK9 inhibitors and ezetimibe or for LDL-c. Results As expected, genetically mimicking statins was inversely associated with LDL-c, apolipoprotein B (ApoB), and total cholesterol (TC) and positively associated with glycated hemoglobin (HbA1c) and was related to body composition. Genetically mimicking statins was also inversely associated with serum calcium, sex hormone-binding globulin (SHBG), and platelet count and positively associated with basal metabolic rate (BMR) and mean platelet volume. Stronger associations with genetically mimicked statins were evident for women than men for lipid traits (LDL-c, ApoB, and TC), calcium, and SHBG, but not for platelet attributes, body composition, or BMR. Genetically mimicking PCSK9 inhibitors or ezetimibe was also associated with lower lipids, but was not related to calcium, SHBG, BMR, or body composition. Genetically higher LDL-c increased lipids and decreased BMR, but did not affect calcium, HbA1c, platelet attributes, or SHBG with minor effects on body composition. Conclusions Similar inverse associations were found for genetically mimicking statins on lipid traits in men and women as for other lipid modifiers. Besides the positive associations with HbA1c, BMI (which may explain the higher BMR), and aspects of body composition in men and women, genetically mimicking statins was additionally associated with platelet attributes in both sexes and was inversely associated with serum calcium and SHBG in women. This genetic evidence suggests potential pathways that contribute to the effects of statins particularly in women. Further investigation is needed to confirm these findings and their implications for clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

A phenome-wide association study of genetically mimicked statins

Schooling

2021

BMC Med

View full text Add to dashboard Cite

show abstract

“…We evaluated PT and aPTT-two assays often used in conjunction-to test, respectively, the extrinsic and the common pathway of coagulation, and the intrinsic and common pathway of coagulation. In addition, we tested fibrinogen, the circulating precursor of fibrin, as well as PLT and MPV, an index of platelet activity and a risk factor for CVD [25]. Also, we measured PAI-1, the main inhibitor of fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control

Palella

Cimino

Pullano

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia to hemostasis and inflammation, however, have been poorly explored in relation to patients’ glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, and neutrophil/lymphocyte ratio (NLR) with T2DM and glycemic control. Research design: In this study, 82 subjects, grouped into T2DM patients (n = 41) and healthy individuals (n = 41) were enrolled. To evaluate glycemic control, the T2DM cohort was expanded to 133 patients and sub-classified according to glycated hemoglobin (HbA1c) <7% and ≥ 7% (n = 58 and n = 75, respectively). We assessed glycemia, HbA1c, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), platelet and leukocyte parameters, vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and selectins (E-, P-, L-). Results: PT % activity, PAI-1, VCAM-1, WBC, and neutrophil counts were significantly higher in T2DM patients than in healthy subjects. Poor glycemic control (HbA1c ≥ 7%) was correlated with increased PT activity (p = 0.015), and higher levels of E-selectin (p = 0.009), P-selectin (p = 0.012), and NLR (p = 0.019). Conclusions: Both T2DM and poor glycemic control affect some parameters of hemostasis, inflammation, and adhesion molecules. Further studies are needed to establish their clinical utility as adjuvant markers for cardio-vascular risk in T2DM patients.

show abstract

“…Platelet counts, MPV, and PDW are indexes obtained quickly, and conveniently, the counts of platelets reflected the number of platelets, which are highly susceptible to the e MPV reflects the volume of platelets and the production of new platelets from bone marrow [22]. Recent evidence also showed that abnormal MPV is linked to diabetes, cardiovascular disease, and autoimmune disorders, as well as PDW [23,24]. However, the MPV reference values are varied among different laboratories [22,25].…”

Section: Discussionmentioning

confidence: 99%

Platelet Distribution Width and Mortality in Hemodialysis Patients

Wang

Jianhua

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objectives. The association between platelet distribution width (PDW) and mortality in hemodialysis (HD) patients has received little attention. Methods. We retrospectively enrolled HD patients in a single center from January 1, 2008, to December 30, 2011. The primary and secondary endpoints were all-cause and cardiovascular mortality, respectively. The association between PDW and mortality was estimated by Cox regression model. Results. Of 496 patients, the mean age was 52.5 ± 16.6 years, and the Charlson comorbidity index was 4.39 ± 1.71. During the follow-up period of 48.8 ± 6.7 months, 145 patients (29.2%) died, including 74 (14.9%) cardiovascular deaths. 258 (52.0%) with PDW < 16.31% were in the low group and 238 (48.0%) in those with PDW ≥ 16.31% according to cut-off for all-cause mortality by receiving-operator characteristics. After adjusting for confounding factors, high PDW values were independently associated with higher risk of all-cause (hazards ratio (HR) = 1.49, 95% confidence interval (CI) 1.15–6.82) and cardiovascular deaths (HR = 2.26, 95% CI 1.44–3.63) in HD patients. When comparing with quartile 1 of PDW, quartile 4 of PDW was independently associated with a higher risk of all-cause (HR = 1.59, 95% CI 1.18–5.30) and cardiovascular deaths (HR = 2.71, 95% CI 1.49–3.76) in HD patients. Conclusions. Baseline PDW was independently associated with all-cause and cardiovascular mortality in HD patients.

show abstract

Mean platelet volume and coronary artery disease

Cited by 44 publications

References 85 publications

A phenome-wide association study of genetically mimicked statins

A phenome-wide association study of genetically mimicked statins

Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control

Platelet Distribution Width and Mortality in Hemodialysis Patients

Contact Info

Product

Resources

About