Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid

Rifaioğlu, Emine Nur; Şen, Bilge Bülbül; Ekiz, Özlem; Doğramacı, Asena Çiğdem

doi:10.3109/09537104.2013.784735

Cited by 17 publications

(20 citation statements)

References 24 publications

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“…7,8,[16][17][18][19][20] The basis of our study was the suspicion that platelet activation and EC are predictive factors for damaged venoocclusive mechanism and endothelial damage, which has a role in ischemic pathophysiology.…”

Section: -13mentioning

confidence: 88%

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

Sönmez

Kara

Karaibrahimoğlu

et al. 2017

CUAJ

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Introduction: We evaluated the relation between ischemic priapism (IP) and blood count parameters in IP patients. We especially wanted to examine the contribution of eosinophil count (EC), platelet count (PC), and mean platelet volume (MPV) values, which are suspected predictive parameters for vascular endothelium damage and venoocclusive pathogenesis and etiopathogenesis, particularly in IP. Methods: A total of 40 IP patients fulfilled the study criteria. Forty healthy volunteers in a similar age group were included as the control group. Complete blood count values were compared between the two groups. Intergroup comparisons were performed using the Mann-Whitney U test, and the chi-square test was used to assess the relationship between categorical variables in the patient groups. The area under the curve was calculated by receiver operating characteristic (ROC) regression analyses. Epidemiological diagnosis percentages were calculated by finding cutoff values. Results: The IP group's high MPV, PC, and EC values compared to those of the control group were detected to be statistically significant (p<0.001, p=0,03, p=0.001, respectively). No statistically significant difference was observed between the two groups for other blood count parameters. Statistically significant values for IP were measured as MPV: positive predictive value: 84%; EC: positive predictive value: 71.4%; and PC: positive predictive value: 61.4%. Conclusions: High MPV, PC, and EC values are significant positive predictive factors in IP etiopathogenesis. No proof was detected for other blood count parameters playing an active role in IP etiopathogenesis.

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Section: -13mentioning

confidence: 88%

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

Sönmez

Kara

Karaibrahimoğlu

et al. 2017

CUAJ

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“…Platelet parameters might be influenced by coronary risk factors including age, obesity, smoking, diabetes mellitus, hypertension, hyperlipidemia, metabolic syndrome, stroke, peripheral artery disease, and deep vein thrombosis [101]. MPV can also be affected by thyroid diseases, bullous pemphigoid, malignancy, and medications such as anticoagulant therapy and statins [102,103]. Karaman, et al [104] initially reported that MPV values significantly decreased after treatment in all grades of prostatitis and BPH.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Impact of Some Selected Plants on Haematological Parameters of Testosterone and Estradiol Induced Benign Prostatic Hyperplasia Adult Male Rats

Ugwu

Asuk

Eteng

et al. 2019

IBRR

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Background: Benign prostate hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostate enlargement. The effect of Prosopis africana (PA), Vernonia amydalina (VA) and Ocimum gratissmum (OG), plant extracts on haematological parameters of BPH animal model was investigated. Methods: BPH was induced in 45 male Wistar rats (250-350 g) by exogenous injection of testosterone and estradiol in staggered doses for 3 weeks. To confirm BPH induction, some animals were sacrificed; histological inspection of prostate gland and PSA was carried out. Forty BPH induced rats were divided into 8 groups. Group 1 and 2, 3 and 4, 5 and 6 were treated with 50 mg/kg bw and 100 mg/kg bw doses of PA, VA and OG extracts respectively. Group 7 received finasteride (0.1 mg/kg bw). Group 8 BPH control and five rats without induction constitute group 9, the normal control and both received distilled water. After 45 days, the rats were anaesthetised by a brief exposure to trichloromethane vapour and 5 ml of blood was collected from the rats through cardiac puncture and dispensed into well-labelled EDTA containers to avoid coagulation. All analyses were completed within 24 h of sample collection. Results: Results showed that induction of BPH caused a significant (P< 0.05) enlargement of prostate gland when compared to normal control. All extracts produced significant (P<0.05) reduction in the weight of the enlarged prostate when compared to the BPH control. There were significant (P ˂0.05) decline in RBC, PCV and Hb of BPH control when compared to the normal control and treated groups. In the treated groups the administration of the extracts and standard drug exhibited an increase in RBC, PCV and Hb concentration when compared with the BPH control. Also there was significant (P < 0.05) increase in the WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils levels in BPH control when compared to normal control and treated groups. In all treated groups there was significant decrease in WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils concentration levels when compared with the BPH control group. Conclusion: The result of this study indicates that the extracts have the potential to reverse the inflammation caused by BPH and also have the capacity to boost the numbers of red blood cells probably by inhibiting the hemolysis caused by inflammatory factors or by enhancing the production of red blood cell from the bone marrow.

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“…In fact, although the role of the blood coagulation system including platelets has not yet been investigated in experimental models of BP, some evidence exists on the relationship between inflammation and coagulation. It has been reported that patients with BP show elevated levels of tissue factor, D‐dimer, prothrombin fragment F1+2 and mean platelet volume and that they have an increased risk for thrombotic events …”

Section: Discussionmentioning

confidence: 99%

“…Previous studies demonstrated that symptoms of patients with BP are associated with a plethora of raised cytokines and chemokines in sera and blister fluids . Moreover, the activation of the coagulation cascade seems to be involved in the disease pathophysiology …”

Section: Introductionmentioning

confidence: 99%

Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid

Bieber

Ernst

Tukaj

et al. 2017

Experimental Dermatology

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Experimental models of bullous pemphigoid (BP), the most frequent subepidermal autoimmune bullous disease, revealed that the immune response leading to blister formation represents an incompletely understood complex process involving different inflammatory cells. In contrast to previous reports commonly focusing on limited molecular and cellular phenotypes of the disease, the aim of this study was to investigate a broad spectrum of markers of cellular immune activation in patients with BP. We found that serum levels of soluble CD4, myeloperoxidase, S100A12, eosinophil cationic protein and soluble P-selectin were significantly elevated in patients with active BP compared with normal controls. Mast cell tryptase and neopterin serum levels significantly decreased at the time of clinical remission of the patients. Additionally, serum concentrations of soluble IL-2 receptor, mast cell tryptase and soluble P-selectin were significantly associated with levels of circulating anti-BP180 autoantibodies. Our findings confirm and extend previous reports suggesting some concomitant involvement of a panel of molecules representative for a wide spectrum of cellular players (T cells, mast cells, neutrophils, eosinophils, macrophages and platelets) orchestrating the inflammatory reaction in BP. These data may favour the employment of broad-spectrum or combined immunosuppressants, potentially together with an anticoagulant treatment, over cell- or molecule-specific targeted therapy in patients with this disorder.

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Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid

Abstract: In this study high levels of MPV and eosinophil levels have been detected. MPV may be a useful indicator of the risk of vascular events. Prospective studies are needed to compare disease activity, thromboembolic events and MPV in BP patients.

Cited by 17 publications

References 24 publications

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

Evaluation of Impact of Some Selected Plants on Haematological Parameters of Testosterone and Estradiol Induced Benign Prostatic Hyperplasia Adult Male Rats

Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid

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