Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease

Wada, Hideki; Dohi, Tomotaka; Miyauchi, Katsumi; Shitara, Jun; Endo, Hirohisa; Doi, Shinichiro; Tsuboi, Shuta; Ogita, Manabu; Iwata, Hiroshi; Kasai, Takatoshi; Okazaki, Shinya; Isoda, Kikuo; Suwa, Satoru; Daida, Hiroyuki

doi:10.1016/j.atherosclerosis.2018.08.048

Cited by 37 publications

(36 citation statements)

References 39 publications

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“…Our results are consistent with previous experimental findings that demonstrated that large platelets may be more likely activated, leading to platelet adhesion and aggregation, resulting in a pro-atherosclerotic effect [30, 31]. Large platelets are rich in secretory granules and have a stronger metabolism and enzyme activity.…”

Section: Discussionsupporting

confidence: 93%

“…Patients with high MPV and high troponin levels had a 4.8-fold increased risk of coronary artery disease [29]. However, a previous study suggested that lower MPV levels were associated with the incidence of MACE in patients with stable angina [30]. Taken together, the relationship between changes in platelet volume and the progression of coronary heart disease may be inconsistent in different subtypes of CAD, which should be confirmed in future studies with larger sample sizes.…”

Section: Discussionmentioning

confidence: 99%

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Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Wang

et al. 2019

BMC Cardiovasc Disord

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Background The association between mean platelet volume (MPV) and coronary plaque vulnerability in patients with non-ST-elevation ACS (NSTE-ACS) has not been investigated. We performed a retrospective study to evaluate the association between MPV and plaque vulnerability using optical coherence tomography (OCT). Methods Consecutive NSTE-ACS patients who underwent pre-intervention OCT examination in our center were included in this study. Features of coronary plaques in the culprit arteries were classified as rupture, nonrupture with thin-cap fibroatheroma (TCFA), and nonrupture and non-TCFA. ROC analyses were used to determine the predictive efficacy of MPV for plaque rupture, and multivariate logistic regression analysis was performed to evaluate the potential independent predictors of plaque vulnerability. Results Overall, 94 patients were included in this study. We identified 17 patients with plaque rupture, 10 with nonrupture with TCFA, and 67 with nonrupture and non-TCFA. ROC analyses showed that MPV ≥ 10.5 fL was predictive of plaque rupture in NSTE-ACS patients. Univariate analyses indicated that patients with higher MPV (≥ 10.5 fL) had higher body mass index and poorer lipid profiles compared to those with lower MPV. Moreover, those with higher MPV had higher incidences of plaque rupture and thrombosis (both P < 0.05). Results of multivariate analyses showed that diabetes and higher platelet distribution width (PDW) were independent risk factors of TCFA ( P = 0.032 and 0.046, respectively), while diabetes, higher BMI, higher PDW, and higher MPV were independent determinants of plaque rupture in our cohorts (P all < 0.05). Conclusions Higher MPV is independently associated with higher risk of plaque rupture as evidenced by OCT in our cohort of NSTE-ACS patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Wang

et al. 2019

BMC Cardiovasc Disord

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“…Inflammatory markers, which are associated with early pregnancy loss in various studies, are not available in all centers due to technical difficulties and high costs. The diagnostic value of systemic inflammatory markers such as NLR, PLR, PDW, MPV, PCT, RDW in many diseases such as preeclampsia, coronary artery disease, autoimmune diseases, inflammatory diseases has already been shown in several studies [15,16]. However, there are few studies and insufficient data in the literature on the relationship between these markers and early pregnancy loss.…”

Section: Discussionmentioning

confidence: 99%

Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss?

Oğlak

Aydın

2020

Ginekol Pol

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Objectives: Red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have all been identified as systemic inflammatory markers. The aim of this study to investigate whether the use of systemic inflammatory markers can predict early pregnancy loss. Material and methods: A total of 137 patients with early pregnancy loss was compared with 148 participants in the control group who had given birth at term. In the study group, CBC values were included in the study at the time of referral to the hospital for routine follow-up, while patients did not experience early pregnancy loss. In the control group, CBC values of the patient before the seventh week of pregnancy were included in the study. results: There was no significant difference between the two groups in terms of RDW, MPV, PCT and PDW values. The NLR and PLR values were significantly higher in the early pregnancy loss group than the control group (p < 0.05). Conclusion: Our findings suggest that high NLR and PLR values are potent markers for the prediction of early pregnancy loss.

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“…In this last systematic review, the authors found that patients with MPV values greater than 7.3 were more likely to present CAD than those with lower values. 8 On the other hand, Wada et al 9 found an association between lower MPV values and the presence of stable CAD. 9…”

mentioning

confidence: 99%

“…8 On the other hand, Wada et al 9 found an association between lower MPV values and the presence of stable CAD. 9…”

mentioning

confidence: 99%

The Search for New Prognosis Markers for Coronary Artery Disease

Pereira

Paiva

2019

Arquivos Brasileiros De Cardiologia

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Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease

Cited by 37 publications

References 39 publications

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss?

The Search for New Prognosis Markers for Coronary Artery Disease

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