Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism

Yardan, Türker; Meriç, Murat; Katı, Celal; Çelenk, Yıldıray; Atıcı, Atilla Güven

doi:10.1186/cc14408

Cited by 8 publications

(9 citation statements)

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“…However, the mechanisms to explain the correlation between MPV and PDW and those clinical outcomes remain unclear, and the prognostic consistency is controversial. Most reports have shown that reduced MPV and/or MPV/P were linked to unsatisfactory prognosis in several carcinomas . However, in advanced NSCLC studied by Omar et al, they found elevated MPV and MPV/P could be an indicator of poor prognosis regarding OS, which is consistent with our current study.…”

Section: Discussionsupporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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Objectives To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X‐tile, and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis. Results The optimal cut‐off points of 171.4 for PLR, 260 × 109/L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P < .05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P < .05). Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.

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Section: Discussionsupporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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“…In our study there was positive correlation between MPV and RVD similar to before studies (5,21). Right ventricle enlargement with increased pulmonary artery pressure can be accepted as hemodynamic indicators and both of them can show the the severity of pulmonary arterial vasculature thrombotic occlusion (18).…”

Section: Discussionsupporting

confidence: 90%

“…Thrombosis commences with the aggregation of erythrocytes, fibrin, and platelets. Platelets have a major role in the pathogenesis of thromboembolic disease (5). Mean platelet volume (MPV), a measurement of platelet size, which is available in every blood count, is progressively recognized as a significant marker of platelet activity (6).…”

Section: Introductionmentioning

confidence: 99%

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Telo¹,

Kırkıl²,

Kaman³

et al. 2017

J Turgut Ozal Med Cent

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Aim: The aim of this study is to investigate the changes in platelet indexes, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PC), in patients with acute pulmonary embolism (PE), in addition to evaluating the diagnostic value in clinical forms. Material and methods: The study consisted of 84 patients with PE and the control group consisted of 40 healthy subjects. PE patients were divided into two groups in accordance with the clinical forms as 60 submassive and 24 nonmassive. The differences in platelet count, MPV, PDW, PC, D-dimer, and other indicators were analyzed between the two groups. Venous peripheral blood samples to measure the MPV, PDW and PC were acquired on admission. Results: MPV levels were found to be statistically higher in the submassive group compared to the nonmassive group and the control group (p<0.01 and p<0.001, respectively). PDW levels were found to be statistically higher in the submassive group compared to the non-massive group and control group (p=0.027 and p<0.001, respectively). PC was significantly lower in the submassive group compared to the non-massive group and control group (p=0.022 and p<0.001, respectively). It was determined that a positive correlation existed between the MPV and right ventricular diameter (RVD) (r=0.27, p<0.01). Conclusion: High MPV and PDW levels and low PC may be indicators of the severity of acute PE. Also, the correlation between the MPV and RVD suggests that MPV can be used as a marker of right ventricular function.

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“…Naess et al reported that secondary cancer VTE is associated with increased mortality relative to secondary non-cancer VTE and idiopathic VTE [25]. According to a study by Yardan et al [26], a high MPV/PLT ratio is associated with RV dysfunction and clinical severity in patients with acute PE and a low MPV/PLT level might be an indicator of low bleeding risk in patients with acute PE. In our study, the APACHE II score and PDW were independent prognostic factors of survival (but not MPV/PLT).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary embolism in non-brain tumor patients after surgery—a retrospective study in China

et al. 2017

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BackgroundThe incidence rate of pulmonary emboli (PE) is high in tumor patients; however, the morbidity and mortality associated with the development of PE after tumor surgery are unknown. We studied the clinical profiles and outcomes of patients with PE after non-brain tumor surgery.MethodsWe retrospectively screened 55,967 patients who underwent non-brain tumor surgery at the Peking University Cancer Hospital from January 2008 to June 2015. Among them, 76 patients who were diagnosed with PE were enrolled in our study. Factors impacting the overall survival at 90 days were analyzed. A Kaplan-Meier curve was plotted for time to death or until day 90. Cox proportional hazard modeling was performed for univariate- and multivariate-adjusted factor analyses.ResultsThe morbidity rate was approximately 135.8 per 100,000 non-brain tumor surgery patients (possibly underestimated). When treated, seven patients had major bleeding, and 14 patients had clinically relevant non-major bleeding, which represented 9.2 and 18.4% of all the patients, respectively. The 3-month overall mortality rate was 11.8% in our study. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score and platelet distribution width (PDW) were independent risk factors for the prognosis of PE after non-brain surgery (P values of 0.001 and 0.016, respectively).ConclusionsTreatment of PE in non-brain tumor surgical patients remained a challenge due to the high bleeding rate. The APACHE II score and PDW were independent prognostic factors of survival in patients with PE after non-brain tumor surgery; however, the study power was limited.

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Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism

Cited by 8 publications

References 0 publications

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Pulmonary embolism in non-brain tumor patients after surgery—a retrospective study in China

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