Mean Platelet Volume and Platelet Function Analysis in Acromegalic Patients Before and after Treatment

Abstract

Objective. Mean platelet volume (MPV) and platelet function analysis have been studied before in acromegaly, but the effect of treatment on both parameters has not been evaluated. We aimed to investigate MPV and platelet function analysis in acromegalic patients after sixmonths of treatment. Methods. Forty patients with active acromegaly and 36 healthy subjects were included in the study. Plasma glucose and lipids, fibrinogen, GH, IGF-1 levels, MPV and platelet function analysis were measured. All patients with acromegaly were re-evaluated six months after treatment. Results. Fasting blood glucose (FBG), GH, IGF-1, fibrinogen levels and MPV values were significantly higher in acromegalic group compared with the control. Platelet function was enhanced significantly (pcol-ADP: 0.002, pcolepinephrine: 0.002). After 6 months of treatment FBG, serum GH, IGF-1, fibrinogen and MPV decreased and collagen/ADP-and collagen/epinephrine-closure times (CT) were increased. Acromegalic patients that were in remission with long-acting SSA after surgery had significantly higher fibrinogen levels and MPV and decreased collagen/ epinephrine-CT with respect to the controls (pfibrinogen: 0.001, pMPV: 0.026, pcol-epinephrine: 0.037). Conclusion. Acromegaly was associated with increased MPV and enhanced platelet activity. Although growth hormone hypersecretion was controlled by surgery and medical treatment, these parameters did not improveindicating a still increased risk for cardiovascular events.

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Systemic Immune-Inflammation Index as Potential Biomarkers of Chronic Inflammation in Patients with Newly Diagnosed Acromegaly: A Single-Centre Study

“…Although, we failed to find any distinctions in MPV and MPV/PLT values between the three analyzed groups. These results are in contrast with those obtained by Arpaci et al, Demirpence et al, and Unübol et al, who noted significantly higher MPV value in acromegaly compared to healthy individuals [34,35,37].…”

“…Until now, there is only a single study concerning the relationship between SII and pituitary adenomas [32]. In accordance with previous data, we proved that the median platelet count was the lowest in patients with acromegaly compared with NFPAs and controls, but no statistical intergroup differences were observed [35]. It is well established that acromegaly is associated with increased morbidity and mortality due to cardiovascular diseases [5].…”

“…However, little is known about hematological parameters in patients with acromegaly and NFPAs. There are only single studies evaluating the relationship between these direct and indirect blood cell-associated inflammatory indices and pituitary tumors [32][33][34][35][36][37].…”

Changes in complete blood count parameters influenced by endocrine disorders

“…The treatment with SSA may thus increase MPV and be associated with greater risk of cardiovascular diseases. Demirpence et al demonstrated a significant decrease in MPV following surgery without adjuvant therapy [35]. MPV values remained unchanged in the active phase of the disease and in patients in remission who received SSA after surgery.…”

“…Research on MPV in acromegaly is inconclusive. Several studies have shown an increased MPV in acromegaly compared to healthy individuals [34][35][36], while another demonstrated no significant differences [37,38]. Surgical treatment with concomitant use of SSA was found to either increase or decrease MPV, whereas in patients treated only surgically no changes of MPV were noted [31,37].…”