Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study

Marzouk, Huda; Lotfy, Hayam M.; Farag, Yomna; Rashed, Laila Ahmed; El-Garf, Kamal

doi:10.1155/2015/152616

Cited by 6 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is frequently found to be decreased in the presence of active high grade inflammation; that is, active phase of RA, AS, ulcerative colitis and Chron disease [ 27 , 41 , 42 ] activation of systemic lupus erythematosus (SLE) arthritis [ 43 ] and active SLE. [ 44 ] Increased MPV levels were on the other hand mainly found in states of low grade inflammation such as: cellulitis, [ 45 ] idiopathic subjective tinnitus, [ 46 ] symptom/attack-free periods of familial Mediterranean fever patients [ 47 , 48 ] and irritable bowel syndrome, [ 49 ] obstructive sleep apnea syndrome. [ 50 ] Being a state of low grade systemic inflammation, OA, is also expected to be associated with higher levels of MPV and this is demonstrated in our study.…”

Section: Discussionmentioning

confidence: 99%

Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity

et al. 2017

View full text Add to dashboard Cite

Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to evaluate the levels of blood PLR and MPV in radiographic hip OA. A total of 880 patients were evaluated retrospectively and after certain exclusion criteria, 237 of them who have primary hip OA were included. Age, sex, height, weight, body mass index, neutrophil, lymphocyte and platelet counts, erythrocyte sedimentation rate (ESR), PLR, and MPV levels were recorded, Kellgren–Lawrence (KL) grading of the hip joints were performed. Patients were then divided into 2 groups as KL grades 1 to 2 (mild–moderate) and KL grades 3 to 4 (severe) hip OA.Mean age, mean neutrophil, lymphocyte and platelet counts, mean MPV, mean PLR, and mean ESR were statistically significantly different between mild/moderate hip OA group and severe hip OA group. In univariate analysis, older age and higher MPV, PLR, and ESR were severely associated with severe hip OA. In multiple logistic regression analysis, MPV, PLR, and ESR emerged as independent predictors of severe hip OA.The results of the present study, for the first time in the literature, suggest blood PLR and MPV as novel inflammatory markers predicting the radiographic severity of hip OA in the daily practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A significant correlation was evident between thrombocyte activation and splenomegaly in FMF children in remission. The mean platelet volume, which reflects platelet function and activation, was higher in FMF patients (16).…”

Section: Discussionmentioning

confidence: 86%

Sonographic evaluation of intra-abdominal organs in children with familial Mediterranean fever

Sönmezgöz

Sönmezgöz²

2021

Journal of Health Sciences and Medicine

View full text Add to dashboard Cite

Objective: The reticuloendothelial system is rarely assessed in patients with familial Mediterranean fever (FMF). We aimed to evaluate the size of the liver and spleen by ultrasonography in children and adolescents with FMF and compare it to their healthy peers. Material and Method:Patient data were evaluated by height, weight, and age and compared with those of healthy controls.Results: A total of 86 children with FMF diagnosed using the Turkish Pediatric Criteria and 54 healthy children were included. The extent of splenomegaly was 27.9% in the FMF group. The mean spleen length was 99.84±17.4 mm in patients and 93.44+15.49 mm in controls (p=0.03). The mean liver length was 122.61±17.4 mm in patients and 117.71±16.04 mm in controls (p=0.104). FMF appears to affect spleen length independently of anthropometric data (t=2.182; p=0.031). Splenomegaly was accompanied by the M694V (32.55%, n=17) and E148Q (3.4%, n=3) mutations. Conclusion:FMF affects spleen length independently of anthropometric data. Splenomegaly may reflect subclinical inflammatory activity in FMF patients in remission. Spleen size can serve as a marker of subclinical inflammation during remission.

show abstract

“…Similarly, Ozkayar et al reported that FMF patients without AA had significantly higher MPV level compared to the control group [19]. In 2015, Marzouk and colleagues found that 84% of the patients with FMF had high MPV levels and they proposed that MPV values may be used as useful markers of subclinical activity in Egyptian children with FMF [17].…”

Section: Discussionmentioning

confidence: 99%

“…Due to these relationships between inflammatory activity and MPV value, MPV has been suggested by many to be a marker of inflammatory activity in various diseases [9,15,16]. The MPV levels in FMF have been previously studied [17]. However, whether MPV levels in FMF patients are lower or higher compared to healthy subjects remains as a topic of ongoing debate.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

et al. 2019

View full text Add to dashboard Cite

Background Amyloidosis is a protein-misfolding disease characterized by the deposition of aggregated proteins in the form of abnormal fibrils that disrupt tissue structure, ultimately causing disease. Amyloidosis is very frequent in untreated familial Mediterranean fever (FMF) patients and it is the most important feature that determines the prognosis of FMF disease. The mean platelet volume (MPV) in FMF has been previously studied. However, whether MPV level in FMF patients is lower or higher compared to healthy controls remains a topic of ongoing debate. In this study, we aimed to investigate MPV values and to assess the correlation between MPV and proteinuria in patients with AA amyloidosis and AA amyloidosis secondary to familial Mediterranean fever (AA-FMF) through a retrospective chart-review. Material/Methods This study was carried out on 27 patients with AA amyloidosis, 36 patients with AA amyloidosis secondary to FMF (a total of 63 patients with AA), and 29 healthy controls. There was no statistically significant difference between the AA patients and the control group (p=0.06) or between the AA-FMF group and the control group in terms of MPV values (p=0.12). Results We found a statistically significant negative correlation between MPV and thrombocyte count in all groups (p<0.05 for all groups), but there was no correlation between MPV and proteinuria levels in AA patients (p=0.091). Conclusions While similar results also exist, these findings are contrary to the majority of previous studies. Therefore, further controlled clinical prospective trials are necessary to address this inconsistency.

show abstract

Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study

Cited by 6 publications

References 35 publications

Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity

Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity

Sonographic evaluation of intra-abdominal organs in children with familial Mediterranean fever

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

Contact Info

Product

Resources

About