Mean Platelet Volume as a Potential Predictor of Renovascular Thrombosis After Renal Transplant

Abstract

artIClE AbstractObjectives: We sought to evaluate the importance of mean platelet volume as a marker to follow-up, the tendency for hemorrhagic diatheses, and/or thrombotic complications in patients before and after renal transplant. Materials and Methods: Thirty-four patients (aged, 5 to 18 y) were included. Demographics of the patients, cause of chronic renal failure, dialysis modality, duration of dialysis, arterio-venous fistula thrombosis, and posttransplant immunosuppressive regimens were recorded and laboratory variables were evaluated. Results: At the end of the first posttransplant month, mean platelet volume level was decreased significantly when compared with pretransplant levels (8.3 ± 1.5 vs 7.7 ± 0.9; P = .04). A significant increase was observed in platelet levels during posttransplant measures (273.750 ± 97.700 vs 318.740 ± 84.586; P = .02). Prothrombin time and partial thromboplastin time levels did not differ before and after transplant. None of the patients had any thrombotic events and/or renal allograft loss. A negative correlation was observed between mean platelet volume and C-reactive protein (r=-0.53). Mean platelet volume level was not found to be related to the cause of renal failure, pretransplant dialysis modality, or posttransplant immunosuppressive regimens. Conclusions:Platelet numbers increased and mean platelet volume decreased after pediatric renal transplant, but the potential for increased thrombosis was not observed.

Clinical importance of mean platelet volume in children with nephrotic syndrome

“…Recent studies were shown a significant negative correlation between platelet count and MPV in chronic illness. 6,7 Thrombocytosis associated with low level -but in normal range -of MPV has been shown in diseases such as inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis and ankylosing spondylitis and these findings is more prominent in the active period of the disease. This finding can be used as an indicator of the disease activity.…”

Contribution of platelets indices in the development of contrast-induced nephropathy

“…Platelet morphology and size distribution were established as important factors affecting endothelial integrity in patients with coronary heart disease [11][12][13][14][15]. Importantly, correlation between platelet morphology and renal failure was reported in glomerulonephritis and postrenal transplantation [16][17][18]. It was also noticed that mean platelet volume (MPV) could serve as a marker of renal dysfunction in patients with stable angina [19].…”

Mean Platelet Volume After Renal Transplant: Time Is Important

“…1 This study showed that platelet numbers increased, and mean platelet volume levels decreased, after a pediatric renal transplant. However, I want to make a minor criticism of this study: In the Methods section, the authors failed to mention the time between sample collection and laboratory analysis.…”