Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease

Ulaşlı, Sevinç Sarınç; Özyürek, Berna Akıncı; Yılmaz, Eylül Bozkurt; Ulubay, Gaye

doi:10.20452/pamw.1284

Cited by 74 publications

(90 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regard to the changes in mean platelet volume levels, our findings are in line with the results of a study by Ulasli et al, 10 who demonstrated that in the exacerbation period of COPD, mean platelet volume levels were decreased. On the contrary, they failed to detect a correlation between mean platelet volume and C-reactive protein, probably due to their small sample size, the baseline increased level of C-reactive protein, or the high mean platelet volume levels in the stable period.…”

Section: Discussionsupporting

confidence: 92%

“…15,16 In our study, WBC count and the percentage of neutrophils were significantly higher compared with during the stable period, as were the C-reactive protein levels, although not normalized, as expected. 16 The investigators of the above studies 10,11 favor this view. However, the intensity of inflammation during COPD exacerbation could lead to reverse results (ie, increased mean platelet volume).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation

Agapakis¹,

Massa

Hantzis³

et al. 2015

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Studies have supported the correlation between mean platelet volume and COPD. However, there are limited data on the relationship between COPD exacerbation and mean platelet volume. We aimed to evaluate the mean platelet volume trend in patients with COPD exacerbation. METHODS: A total of 81 subjects, 62 men and 19 women, who were admitted to the hospital because of exacerbation of COPD during 9 months, were enrolled in this prospective observational study. The levels of mean platelet volume, C-reactive protein, complete blood count, and percentof-predicted FEV 1 were measured in subjects at admission (exacerbation period) and after 3 months (stable period). Thirty-seven age-and sex-matched healthy individuals constituted the control group. RESULTS: Subjects in the exacerbation period had significantly higher levels of C-reactive protein (P ‫؍‬ .001), white blood cell count (P ‫؍‬ .01), and percentage of neutrophils (P ‫؍‬ .01) and lower percent-of-predicted FEV 1 than in the stable period (P ‫؍‬ .02). Mean platelet volume levels were significantly decreased in the exacerbation period (P ‫؍‬ .001). Considering a cut-off point of mean platelet volume levels <8.2 fL for indicating COPD exacerbation showed a sensitivity of 80% and a specificity of 76%. Also, mean platelet volume levels correlated significantly with increase of C-reactive protein level, white blood cell count, and neutrophil percentage in the exacerbation period (P ‫؍‬ .01, P ‫؍‬ .01, and P ‫؍‬ .02, respectively). CONCLUSIONS: Mean platelet volume may be an inflammatory marker in exacerbation of COPD, and the measurement of mean platelet volume values may be useful for identifying patients who are at increased risk for exacerbations of illness.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation

Agapakis¹,

Massa

Hantzis³

et al. 2015

Respir Care

View full text Add to dashboard Cite

show abstract

“…However, there was no correlation between logarithmic values of MPV, CRP and platelet values in patient groups. Yuksel et al, Ulaslı et al, as well reported that no correlation was observed between CRP and MPV in patients with ulcerative colitis and chronic obstructive pulmonary disease, respectively 8,27 . The findings of our study were in line with the results of these previous studies.…”

mentioning

confidence: 98%

Mean platelet volume in brucellosis: correlation between brucella standard serum agglutination test results, platelet count, and C-reactive protein.

Okan

Zararsız²,

Seyit

et al. 2015

Afr H. Sci.

View full text Add to dashboard Cite

Background: Brucellosis, a zoonotic infection, was most widely diagnosed by the Brucella standard serum agglutination test (SAT). No previous publication has demonstrated a correlation between the degree of Brucella SAT agglutination positivity and the severity of brucellosis infection. Objective: To contribute to the clarification of the relationship between patelets and brucellosis. It is also aimed at evaluating the usefulness of the SAT titer as a measure of brucellosis severity. Material and Methods: We compared the control (n=60) and patients (n=96) groups in terms of mean platelet volume (MPV), C-reactive protein (CRP) and platelet values. Patients were grouped according to their degree of agglutination positivity titers and compared by means of CRP, MPV and platelet values. We also investigated the relationship among logarithmic values of MPV, platelet and CRP parameters for each group. Results: Although statistically meaningful difference was observed between control and patients group in terms of MPV and platelet value, there were no statistically significant differences observed among patients groups. The physiological negative correlation between MPV and platelet count was not encountered in group 2 and 3. Logarithmic values of CRP were not correlated with logarithmic values of MPV and platelet counts. Conclusion:The MPV could be a new parameter to evaluate hematologic abnormalities in patients with brucellosis. The SAT titer was not a useful measure for evaluation of the severity of brucellosis.

show abstract

“…Additionally, higher MPV correlates well with an increased number of platelet-platelet aggregates, and the elevated MPV values are linked with a shortened bleeding time, increased thromboxane A2 and B2 per unit volume and expression of the large amount of adhesion molecules, such as P-selectin glycoprotein 1b and glycoprotein IIb/IIIa (10). Larger platelets are probably younger, more reactive, and create more thrombogenic factors (11). Therefore, large platelets are more agreeable and, metabolically and enzymatically more active compared to small platelets and normal platelets (12).…”

Section: Discussionmentioning

confidence: 99%

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Telo¹,

Kırkıl²,

Kaman³

et al. 2017

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Aim: The aim of this study is to investigate the changes in platelet indexes, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PC), in patients with acute pulmonary embolism (PE), in addition to evaluating the diagnostic value in clinical forms. Material and methods: The study consisted of 84 patients with PE and the control group consisted of 40 healthy subjects. PE patients were divided into two groups in accordance with the clinical forms as 60 submassive and 24 nonmassive. The differences in platelet count, MPV, PDW, PC, D-dimer, and other indicators were analyzed between the two groups. Venous peripheral blood samples to measure the MPV, PDW and PC were acquired on admission. Results: MPV levels were found to be statistically higher in the submassive group compared to the nonmassive group and the control group (p<0.01 and p<0.001, respectively). PDW levels were found to be statistically higher in the submassive group compared to the non-massive group and control group (p=0.027 and p<0.001, respectively). PC was significantly lower in the submassive group compared to the non-massive group and control group (p=0.022 and p<0.001, respectively). It was determined that a positive correlation existed between the MPV and right ventricular diameter (RVD) (r=0.27, p<0.01). Conclusion: High MPV and PDW levels and low PC may be indicators of the severity of acute PE. Also, the correlation between the MPV and RVD suggests that MPV can be used as a marker of right ventricular function.

show abstract

Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease

Cited by 74 publications

References 36 publications

The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation

The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation

Mean platelet volume in brucellosis: correlation between brucella standard serum agglutination test results, platelet count, and C-reactive protein.

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Contact Info

Product

Resources

About