Mean platelet volume does not predict risk of myocardial infarction or coronary artery disease in Indian patients

Damodar, Sharat; Ganesh, Kalyan Vara; Murthy, Sreedhar

doi:10.1080/09537100701658206

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…In contrast to the results obtained in these studies, we did not find any significant difference between platelet count and volume indices of cases. Our findings are in concordance with the findings of A Bhayana et al (1) and Damodar et al (9) who also concluded that raised MPV is not a risk factor for development of acute coronary syndrome. But the mean value of Troponin T with respect to gender was 0.8ng/ml in males and 0.61ng/ml in females.…”

Section: Discussionsupporting

confidence: 83%

Significance of Platelet Parameters and Troponin T in Patients with Acute Coronary Syndrome

Nataraju¹

2017

jmscr

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Section: Discussionsupporting

confidence: 83%

Significance of Platelet Parameters and Troponin T in Patients with Acute Coronary Syndrome

Nataraju¹

2017

jmscr

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“…28 Damodar et al observed that raised MPV is not a risk factor for development of acute coronary syndrome. 29 Our study has few limitations. The sample size is small which may have created a potential bias in the observations.…”

Section: Discussionmentioning

confidence: 92%

Study of platelet indices in hyperlipidemia

Hawaldar¹,

Sodani²

2020

JDPO

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Introduction: Atherosclerosis is a chronic inflammatory condition n resulting from hyperlipidemia and involves platelet mediated recruitment of white blood cells to arteries. The platelet activation is measured indirectly through several platelet indices routinely available without any additional cost in newer fully automated haematology analysers. These indices include platelet count, mean platelet volume(MPV), platelet distribution width(PDW), plateletcrit(PCT), mean platelet(component) concentration (MPC), mean platelet dry mass (MPM), platelet large cell count and platelet large cell ratio (PLCR).. The present study was undertaken in the pathology department of our diagnostic centre to find an association between platelet indices reported by Advia 2120(Siemens) fully automated haematology analyser and hyperlipidemia. Materials and Methods: This was a prospective study carried out in our diagnostic centre from April to July 2018. 100 patients with hyperlipidemia without any associated diseases and 100 controls with normal lipid profile were included in the study. Statistical analysis was done using Pearson's correlation test and data was expressed as mean ±SD for each parameter. A p value of < 0.05 was considered to be significant. Results: Maximum number of patients were in 41-60 years of age (65%). The male to female ratio was 1.7: 1 with 63% males and 37% females. The mean cholesterol ,mean triglyceride and mean HDL cholesterol level in study group was 218.6±36.3, 244.3±154,38.7±9.6 respectively and 158±26.8 ,94.1±34.8,and 42.1±9.3 in control group respectively. Mean LDL cholesterol was 131.1±39.4 in study group and 97.1±25.2 in control group. There was a significant difference in platelet counts in both groups with a p value of 0.01. PCT and MPC also showed a p value of 0.004. The mean platelet mass (MPM) was 2.17±0.2 in study group as compared to 2.13±021 in control group. Large platelet count was 7.09±4.9 in study group while it was 5.95±3.81 in control group which was also significantly different. Conclusion:Our study indicates that PCT, MPM large platelets and platelet count are significantly higher in hyperlipidemia patients.These indices are available without any additional cost to clinicians, pathologists and patients and can be used to assess the risk associated with hyperlipidemia.

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“…This finding is often associated with a transient decrease in platelet count (38,41). Moreover, among patients with coronary artery disease, those with higher platelet volume seem to have a greater risk of AMI than those with lower MPV, regardless of the extent of the coronary lesions (42), although some authors have reported contrasting data (43).…”

Section: Mpv and Coronary Artery Diseasementioning

confidence: 99%

The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases

Vizioli

Muscari

2009

International Journal of Clinical Practice

371

305

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Mean platelet volume does not predict risk of myocardial infarction or coronary artery disease in Indian patients

Cited by 10 publications

References 2 publications

Significance of Platelet Parameters and Troponin T in Patients with Acute Coronary Syndrome

Significance of Platelet Parameters and Troponin T in Patients with Acute Coronary Syndrome

Study of platelet indices in hyperlipidemia

The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases

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