Mean Platelet Volume in Patients with Obstructive Sleep Apnea and Its Relationship with Simpler Heart Rate Derivatives

Abstract

Some studies show increased mean platelet volume (MPV) in obstructive sleep apnea (OSA). The aim of this study was to evaluate MPV in OSA patients without cardiovascular risk factors and the possible association of heart rate derivatives with MPV. A total of 82 patients (aged 30–70 years) were divided into 2 groups according to the presence of either OSA or non-OSA as the control group. The OSA group consisted of 52 patients and the control group consisted of 30 subjects. Neither group was significantly different in terms of MPV values as well as heart rate (HR) derivatives such as minimum HR, maximum HR, the difference between maximum HR and minimum HR, mean HR, and heart rate performance index (HRPI) [(HR max. − HR min.)/HR mean] (P > 0.05 for all variables). In multivariate analysis, platelet count and percentages of recording time spent at arterial oxygen saturation < 90% significant variables are associated with MPV (β ± SE: −0.004 ± 0.002, 95% CI, −0.008 to −0.001; P = 0.034) and (β ± SE: 2.93 ± 1.93, 95% CI, 0.167 to 5.69; P = 0.038). Consequently, our findings predominantly suggest that there is a casual and reciprocal interaction between MPV and autonomic activation.

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

“…Other indices including MPV and plateletcrit were not different then the control. As mentioned above, there are several studies reporting no difference in MPV between patients with OSA and control (13)(14)(15)(16)(17)(18). The studies reporting difference in MPV, found that MPV was higher only in patients with severe OSA (but not milt-moderate OSA) than the control group (4)(5)(6)(7)9).…”

“…Moreover in some studies, it was proposed that treatment with continuous positive airway pressure (CPAP) devices and surgical intervention significantly reduce MPV and PDW values in patients with severe OSA (10)(11)(12)24). On contrary, almost similar number of study reported no relationship between MPV and OSA, and between PDW and OSA (13)(14)(15)(16)(17)(18).…”

“…Moreover continuous positive airway pressure treatment (CPAP) reported to cause a significant decrease in the MPV and PDW values in patients with OSA (10)(11)(12). On contrary, some other studies reported no relationship between MPV and OSA, and between PDW and OSA (13)(14)(15)(16)(17)(18). Because there are controversies among studies, we aimed to investigate platelet indices in our patients with OSA.…”

The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

“…Red cell and platelets indices have been extensively investigated in various diseases. Limited, controversial information is available, however, on the association between red cell [15][16][17][18][19] and platelets [15,[20][21][22][23][24][25] parameters and the severity of OSAS. Therefore, the aim of this study was to investigate the levels of these parameters in patients with OSAS and to assess whether there is any correlation between the severity of OSAS and any of these parameters.…”

Meeting Sleep Guidelines Is Associated With Better Health-Related Quality of Life and Reduced Premature All-Cause Mortality Risk

“…These covariates included demographic, psychological (eg, depression), chronic diseases (eg, diabetes), behavioral (eg, physical activity), and cardiovascular biomarkers (eg, mean platelet volume, white blood cells), all known to associate with sleep. Covariates included age (years; continuous), 14 gender, 14 race–ethnicity (Mexican American, non-Hispanic white, non-Hispanic black, and other), 14 measured body mass index (kg/m2; continuous), 15 education (<ninth grade, 9-11, high school, some college, college or more), 14 cotinine (ng/mL; continuous), 16 white blood cells (1000 cells/μL; continuous), 17 iron (μg/dL; continuous), 18 physician diagnosis of diabetes (yes/no), 19 physician diagnosis of coronary artery disease (yes/no), 20 measured mean arterial pressure (mm Hg; continuous), 20 self-report engagement in moderate-to-vigorous physical activity in the past 30 days (yes/no), 21 mean platelet volume (fL; continuous), 22 red blood cell distribution width (%; continuous), 13 and Patient Health Questionnaire-9 (PHQ-9) determined moderate or greater (PHQ-9 score ≥10) depression symptomology. 23 Details on the assessment of these covariates are reported elsewhere.…”