Mean Platelet Volume Is Increased in Infective Endocarditis and Decreases after Treatment

Abstract

Objectives: The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with infective endocarditis. Subjects and Methods: Twenty-nine patients with infective endocarditis and 29 healthy subjects were studied. Plasma MPV values in patients and control subjects were measured on admission and after 2 weeks of specific treatment of infective endocarditis. Results: The MPV was significantly higher among patients with infective endocarditis when compared with the control group (9.86 ± 1.1 vs. 8.0 ± 1.0 fl, respectively; p < 0.01). The MPV values of patients with infective endocarditis decreased significantly after treatment from 9.86 ± 1.1 to 7.86 ± 1.0 fl (p < 0.01). Total platelet counts increased significantly after treatment from 193.4 ± 96.5 × 10⁹ to 243.7 ± 92.4 × 10⁹ (p = 0.04). Conclusion: MPV values were higher in patients with infective endocarditis and decreased significantly after treatment. Elevated MPV values indicate that patients with infective endocarditis have increased platelet activation and infective endocarditis treatment decreases this platelet activation by decreasing MPV.

Platelet indices in patients with infective endocarditis and embolic events; confounding factors should be considered

“…As a difference from this result, previous studies demonstrated higher MPV in patients with IE who had no embolic event to this in control subjects [5,6]. We believe that if the authors had considered the above-mentioned confounding factors, they would perhaps have found different results.…”

Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit

“…In a study conducted by Becchi et al ., discharge MPV increased and PC decreased in patients who died from sepsis, but the opposite was true for patients who lived . Another study showed that MPV values were higher in patients with infective endocarditis, but these values decreased significantly after treatment .…”

Mean platelet volume and mean platelet volume/platelet count ratio in infective endocarditis

“…The mean platelet volume (MPV) is a platelet index measured routinely as part of a complete blood count (CBC) in most clinical laboratories using automated analyzers [4][5][6][7]. In general, larger platelets are more active and thrombophilic than those of a normal or smaller size [4,7,8].…”

“…The mean platelet volume (MPV) is a platelet index measured routinely as part of a complete blood count (CBC) in most clinical laboratories using automated analyzers [4][5][6][7]. In general, larger platelets are more active and thrombophilic than those of a normal or smaller size [4,7,8]. Consequently, MPV, a platelet size parameter, is used as a marker of platelet activation and function [8], and reflects platelet activation and production in bone marrow [9][10][11][12].…”

“…Embolic events frequently cause lifethreatening complications in IE [7]. Although IE is an infectious disease, antibiotic therapy for the causative microorganisms is not sufficient for its cure [8].…”