Mean platelet volume is not associated with coronary slow flow: A retrospective cohort study

Abstract

Objective:To investigate mean platelet volume (MPV) levels in patients with coronary slow flow (CSF).Methods:465 stable angina pectoris cases with angiographically normal coronary arteries were recruited [coronary slow flow group (n=76), control group (n=389)] in the observational retrospective cohort study. Clinical, biochemical and demographic variables including MPV were noted and coronary blood flow was assessed with TIMI frame count (TFC).Results:Gender, smoking, height, serum creatinine, uric acid levels, hemoglobin, waist/hip ratio, systolic blood pressure but not MPV were significantly different among groups. Independent predictors of CSF were height (p=.029) and serum uric acid level (p=.045). Gender, height, weight, hip circumference, systolic blood pressure, fasting blood glucose, serum urea, creatinine, uric acid levels, hemoglobin and platelet count were associated with mean TFC whereas independent predictors of mean TIMI frame count were height (p=.010) and serum uric acid level (p=.041).Conclusion:Height and serum uric acid level but not MPV were independent predictors of both CSF and mean TFC.

Complete blood cell count components and coronary slow-flow phenomenon

“…In addition to ischemic heart diseases, complete blood cell count components have also been found to be associated with the presence of CSFP; however, study results have been inconsistent in the literature. Several reports have demonstrated that the mean platelet volume is higher in patients with CSFP compared to individuals with normal coronary arteries;10–12 however, in one study the elevated mean platelet volume has not been associated with CSFP 13. Other platelet volume indices, including platelet distribution width and platelet–large cell ratio, have been associated with the presence of CSFP 6.…”

“…On the other hand, the relationship between leukocyte subtypes and the CSFP has been inconsistent in previous studies. In most of the studies, total white blood cell count has not been the predictor of CSFP 6,13–15. In contrast, Akboga et al16 found that a higher white blood cell count is associated with CSFP.…”