Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

Özkan, Bülent; Arık, Osman Ziya; Gözükara, Mehmet Yavuz; Şahin, Durmuş Yıldıray; Topal, Salih; Uysal, Onur Kadir; Elbasan, Zafer; Epçeliden, Tuncay; Çaylı, Murat; Gür, Mustafa

doi:10.1097/mbc.0000000000000108

Cited by 13 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, a higher MPV value has also been associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement [9], whereas a lower MPV value was proven to be a reliable biomarker for the screening of brain injury in patients with mild head trauma [10].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mean platelet volume with four hematological analyzers

Lippi

Pavesi

Pipitone

2015

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

The clinical applications of mean platelet volume (MPV) have recently broadened far beyond the differential diagnosis of platelet (PLT) disorders to embrace diagnosis and prognostication of a variety of thrombotic conditions. As the potential usefulness of this simple and inexpensive parameter may be challenged by instrument heterogeneity, we investigated the degree of analytical quality and interinstrument comparability. One hundred consecutive inpatient samples were simultaneously assessed on Abbott Sapphire, Mindray BC6800, Siemens Advia 2120, and Sysmex XE5000. The within-run imprecision of the four hematological analyzers was also assessed according to the Clinical and Laboratory Standards Institute document EP5-A2. The imprecision of PLT count ranged between 1.4 and 4.3%, and hence was always within the desirable quality specifications. The within-run imprecision of MPV ranged between 1.1 and 3.8%, and hence was also within the desirable quality specifications. The optical and impedance measurements displayed excellent correlations. Overall, the PLT count exhibited a modest instrumental variation, with bias always within the desirable quality specifications. A large bias was instead recorded for MPV, with between-instrument variations exceeding the desirable quality specifications in five out of six interinstrumental comparisons. No significant correlation was also observed between PLT count and MPV with any of the instruments tested. These results attest that although there is an optimal degree of analytical quality and comparability for PLT counting among different hemocytometers, the harmonization of MPV is poor, thus making the adoption of universal cutoffs virtually impossible.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of mean platelet volume with four hematological analyzers

Lippi

Pavesi

Pipitone

2015

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

show abstract

“…Three studies showed that patients with AS had higher PC than controls [24,35,36]. Eleven studies demonstrated lower PC in the patient group [12][13][14]23,[25][26][27]30,32,35,43], and 11 studies found no difference in PC between patients and controls (Table I, Supplementary Table VI) [11,15,28,29,33,37,41,42,44,46,47]. One study did not provide PC results.…”

Section: Pcmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

View full text Add to dashboard Cite

Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

show abstract

“…Increase in prothrombotic activity plays an important role in the developement of atherosclerosis [7]. In previous studies increase in MPV has been found to be related to cardiovascular and cerebrovascular diseases like hypertension, angina pectoris, myocardial infarction, and stroke [12][13][14][15]. In a different study it was concluded that increased MPV normalised with time in ischemic stroke patients and persistant increase was related to poor prognosis [16].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Changes In Mean Platelets Volume In Children With Adenotonsillar Hypertrophy

Arıcıgil¹

2017

JOENTR

View full text Add to dashboard Cite

Objective: Adenotonsillar hypertophy is the most common cause of upper airway obstruction seen in children. Adenotonsillar hypertrophy is known to cause cardiac and pulmonary disfunctions. The most important reason for this is hypoventilation. Hypoventilation could lead to hypercoagulopathy. Mean platelet volume is the most important parameter that shows thrombocyte size. Larger thrombocytes contain more enzymatic granules and this is an indication that more prothrombotic activities will occur. In this study we researched on the changes in Mean platelet levels after adenotonsillectomy in patients with adenotonsillar hypertrophy. Methods:The mean platelet volume of 45 patients of ages 3-9 years were retrospectively evaluated before and after operation due to adenotonsillar hypertrophy between the years 2011-2015.Results: There was no significant difference in Hemoglobin, White blood cells, and Mean Platelet Volume between the preoperative and postoperative values however there was a significant decrease in platelet count. Conclusion:There was no signifant change in Mean Platelet Volume but a decrease in platelet volume was seen in almost 50% of the patients.

show abstract

Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

Cited by 13 publications

References 35 publications

Evaluation of mean platelet volume with four hematological analyzers

Evaluation of mean platelet volume with four hematological analyzers

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Evaluation of Changes In Mean Platelets Volume In Children With Adenotonsillar Hypertrophy

Contact Info

Product

Resources

About