Mean platelet volume-to-platelet count ratio after elective cardiac surgical procedures is superior in reflecting platelets metabolic hyperactivity compared to other routine morphological platelet indices: A preliminary report

Abstract

Background Excessive metabolic excitation of platelets after cardiac procedures may be related to some adverse events but assessment of their metabolic activity is not routine. The purpose of this study was to evaluate which of the basic platelet morphological parameters best reflects their metabolic status. Methods The blood samples of 22 cardiac surgical patients (mean age of 62.3 ± 10.3 years) were taken before surgery (BS), and 1, 24 and 48 hours after the operation. Correlations between morphological platelet parameters (platelet count [PLT], mean platelet volume [MPV], platelet distribution width [PDW] and MPV/PLT) and their metabolic activity (total concentration of malondialdehyde [MDA] and MDA/PLT) were estimated. Results Significant decline in PLT after operation (from 223 ± 44 × 10 12 /L to 166 ± 57 × 10 12 /L) was accompanied by marked increase in MPV (from 8.4 ± 0.9 fL to 9.1 ± 1.2 fL) and no change of PDW. Consequently, MPV/PLT index increased significantly after procedures from (median with IQR) 0.038 (0.030–0.043) to 0.053 (0.043–0.078). Simultaneously, a significant increase in total platelet MDA content and MDA/PLT was noted reaching peak levels soon after operation. The strongest correlation was observed between MPV/PLT and MDA/PLT (r = 0.56; p < 0.001), although the others were also found to be significant (MDA/PLT vs. MPV; r = 0.35; MDA/PLT vs. PDW; r = 0.34). Conclusions Among basic morphological parameters and indices, the MPV-to-PLT ratio reflects the best metabolic status of platelets in cardiac surgical patients.

The Effects of Platelet Indices on Early Mechanical Complications of Peritoneal Dialysis

“…In addition to being the main cell that provides primary hemostasis for tissue healing, platelets mediate the release of cytokines so that other cells necessary for tissue healing migrate to the damaged area [21]. Platelets newly released from megakaryocytes tend to be larger than mature platelets [22]. Based on the view that PIs may reflect the activities of platelets, we planned our study to investigate the effects of PIs on mechanical complications of PD.…”

Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

“…The MPV/PC ratio has been investigated in the diagnosis, prognosis and risk characterization in various diseases, eg, myocardial infarction (MI), sepsis, and metabolic status of platelets in cardiac surgical patients. [13][14][15][30][31][32] Guenancia et al 33 suggested that a high MPV/PC ratio might help to identify acute MI patients at increased risk of inhospital ischemic stroke. To our knowledge, the association of the MPV/PC ratio and NVAF has not been reported till now.…”