Meandered and muddled: a systematic review on the impact of air pollution on ocular health

Muruganandam, Niveditha; Mahalingam, Sneha; Narayanan, Ramsundram; Rajadurai, Elangovan

doi:10.1007/s11356-023-27079-x

Cited by 11 publications

(2 citation statements)

References 199 publications

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“…Furthermore, recent research has brought to light the detrimental effects of PM 2.5 on the surface of the eyes, thereby contributing to the emergence of various eye conditions (Yang et al 2019 ). Studies have shown that PM 2.5 can deposit on the eyelids and eyelashes (Muruganandam et al 2023 ). Short-term or long-term exposure to an environment with excessive air quality can cause eye irritation (eye itching, tears, etc.)…”

Section: Introductionmentioning

confidence: 99%

Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air–liquid interface

Chen,

Ge,

Deng

et al. 2024

Environ Sci Pollut Res

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Fine particulate matter (PM2.5) can enter the human body in various ways and have adverse effects on human health. Human lungs and eyes are exposed to the air for a long time and are the first to be exposed to PM2.5. The “liquid immersion exposure method” has some limitations that prevent it from fully reflecting the toxic effects of particulate matter on the human body. In this study, the collected PM2.5 samples were chemically analyzed. An air–liquid interface (ALI) model with a high correlation to the in vivo environment was established based on human lung epithelial cells (A549) and immortalized human corneal epithelial cells (HCE-T). The VITROCELL Cloud 12 system was used to distribute PM2.5 on the cells evenly. After exposure for 6 h and 24 h, cell viability, apoptosis rate, reactive oxygen species (ROS) level, expression of inflammatory factors, and deoxyribonucleic acid (DNA) damage were measured. The results demonstrated significant dose- and time-dependent effects of PM2.5 on cell viability, cell apoptosis, ROS generation, and DNA damage at the ALI, while the inflammatory factors showed dose-dependent effects only. It should be noted that even short exposure to low doses of PM2.5 can cause cell DNA double-strand breaks and increased expression of γ-H2AX, indicating significant genotoxicity of PM2.5. Increased abundance of ROS in cells plays a crucial role in the cytotoxicity induced by PM2.5 exposure These findings emphasize the significant cellular damage and genotoxicity that may result from short-term exposure to low levels of PM2.5.

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Section: Introductionmentioning

confidence: 99%

Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air–liquid interface

Chen,

Ge,

Deng

et al. 2024

Environ Sci Pollut Res

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“…Air pollution has become one of the key environmental crises, , associated with considerable detrimental human health outcomes. − Among air pollutants, ambient fine particles (AFPs, commonly known as fine particulate matter or PM 2.5 ) are gaining increasing attention in public health. − Strikingly, emerging studies suggested that the AFP pollution could not only affect the eye surface, such as eye discomfort, aberrant tear morphology, and ocular surface inflammation, but also have indirect adverse effects on the inner structures of eyes through inflammatory cytokines. − Liu et al previously reported the presence of black carbon particles at the ocular surface and found a positive association with dry eye disease . AFPs are laden with various pollutants (e.g., heavy meal, polycyclic aromatic hydrocarbons, and pathogens) and will transform once in the biological microenvironment, − generating reactive oxygen species (ROS) and bringing unpredicted health risks .…”

Section: Introductionmentioning

confidence: 99%

Enhanced Intrusion of Exogenous Airborne Fine Particles toward Eyes in Humans and Animals: Where Damaged Blood–Ocular Barrier Plays a Crucial Role

Qi,

Liu,

Chen

et al. 2024

Environ. Sci. Technol.

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Emerging data suggest a close correlation between ambient fine particle (AFP) exposure and eye disorders and pinpoint potential threats of AFPs to eye health in humans. However, the possible passage (including direct intrusion) and the interactions of AFPs with the eye microenvironment in addition to morphological and physiological injuries remain elusive. To this end, the likely transport of AFPs into the eyes via blood−ocular barrier (BOB) in humans and animals was investigated herein. Exogenous particles were recognized inside human eyes with detailed structural and chemical fingerprints. Importantly, comparable AFPs were found in sera with constant structural and chemical fingerprints, hinting at the translocation pathway from blood circulation into the eye. Furthermore, we found that the particle concentrations in human eyes from patients with diabetic retinopathy were much higher than those from patients with no fundus pathological changes (i.e., myopia), indicating that the damaged BOB increased the possibility of particle entrance. Our diseased animal model further corroborated these findings. Collectively, our results offer a new piece of evidence on the intrusion of exogenous particles into human eyes and provide an explanation for AFP-induced eye disorders, with substantially increased risk in susceptible individuals with BOB injuries.

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Air Pollution Principles, Research, and Innovation

Izah,

Sawyer,

Ogwu

et al. 2024

The Handbook of Environmental Chemistry

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Meandered and muddled: a systematic review on the impact of air pollution on ocular health

Cited by 11 publications

References 199 publications

Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air–liquid interface

Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air–liquid interface

Enhanced Intrusion of Exogenous Airborne Fine Particles toward Eyes in Humans and Animals: Where Damaged Blood–Ocular Barrier Plays a Crucial Role

Air Pollution Principles, Research, and Innovation

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