Meandering Ocular Toxocariasis

Sorr, Edward M.

doi:10.1097/00006982-198400420-00003

Cited by 17 publications

(9 citation statements)

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“…Several human cases in which a trace of a larva was seen have been reported 1819 In one case, the trace remained for more than 2 years in a human eye,19 but in our experiment all traces disappeared within 20 days. We can think of three possibilities for the aetiology of the trace: (1) immunological response, (2) direct destruction of retinal layer by larva, and (3) excretory material remaining on the retinal layer.…”

Section: Discussionmentioning

confidence: 40%

New animal model for human ocular toxocariasis: ophthalmoscopic observation

Takayanagi

Akao

Suzuki

et al. 1999

British Journal of Ophthalmology

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Background/aims-Although human ocular toxocariasis causes severe vision defect, little is known about its aetiology, diagnosis, and treatment. To develop a new animal model for human ocular toxocariasis, ophthalmological findings of fundi in Mongolian gerbils, Meriones unguiculatus, and BALB/c mice were investigated following infection with Toxocara canis. Methods-Using an ophthalmoscope, which was specifically developed to observe the fundi of small animals, ocular changes of fundi of 20 gerbils and 11 mice were monitored after oral infection with embryonated eggs of T canis. Results-Vitreous, choroidal, and retinal haemorrhages were consistently observed in Mongolian gerbils, but rarely in mice. Severe exudative lesions and vasculitis were often present in gerbils but not in mice. Migrating larvae were also frequently observed in gerbils. Conclusion-Mongolian gerbils are more appropriate animal model for human ocular toxocariasis than previously used experimental animal such as mice, guinea pigs, rabbits, and monkeys because of its high susceptibility of ocular infection. (Br J Ophthalmol 1999;83:967-972)

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Section: Discussionmentioning

confidence: 40%

New animal model for human ocular toxocariasis: ophthalmoscopic observation

Takayanagi

Akao

Suzuki

et al. 1999

British Journal of Ophthalmology

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“…OLM may be seen as a broad spectrum of ophthalmic disease, including retinal detachment, posterior pole granuloma, uveitis, vitreous abscess, optic neuritis, keratitis, iritis, and hypopyon (Fig. 5, middle, middle right, and right) (150,179,254,299). Strabismus, decreased or loss of vision, esotropia, and leukocoria are typical symptoms (179,228,229,299).…”

Section: Ocular Disease Caused By Cestodesmentioning

confidence: 99%

Fungal and Parasitic Infections of the Eye

Klotz

Penn

Negvesky

et al. 2000

Clinical Microbiology Reviews

181

145

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“…Mostly in adult patients, ocular involvement is thought to be primarily a function of the host immune response to antigens released by dying parasites, while only in a minority of patients a mobile larva is responsible for mechanical or toxic alterations. 1 The common evidence of active inflammation in the absence of the larvae or of their remnants, supports the idea that secreted surface antigens could be responsible for the inflammatory reaction. The hypothesis of a local intense production of antibodies has been strongly supported by: (1) The observation of measurable antibody titres in the vitreous and aqueous humour of affected patients and (2) the presence of plasmacytes in the chorioretinal infiltrates.…”

Section: Discussionmentioning

confidence: 65%

“…When adult people are affected, however, ocular involvement is thought to be primarily a function of the host immune response to antigens released by dying parasites. 1 We report the case of an adult patient with a severe Toxocara endophthalmitis, confirmed by vitreous and blood serology, who revealed persistent ocular inflammation after vitrectomy, anti-parasitic treatment and highdose corticosteroids. Adjuvant oral cyclosporin A (CsA), combined with a lower daily amount of corticosteroids, was successful in achieving a longterm control of the ocular inflammation.…”

Section: Introductionmentioning

confidence: 90%