An existential vacuum is experienced as a kind of crisis that one can cope with using his/her strengths. The related literature suggests that the important determinants of coping with existential emptiness include positive emotional and personality resources, and among these—Curiosity Behaviors. The purpose of this study is to describe the role of curiosity as an important factor in relation to emotional resources in individuals experiencing an existential vacuum. A survey was conducted using online tools (n = 484). The hypotheses about the direct and indirect relationships between Curiosity Behaviors and existential vacuum were tested using multiple regression analyses and mediations. The study involved a sample of adult participants representing the general population. The participants completed five questionnaires, the first one focusing on Curiosity Behaviors, such as seeking out novel and challenging experiences and engagement in activities that capture one’s attention (The Curiosity and Exploration Inventory), and the other tools being the Multidimensional Existential Meaning Scale, the Emotional Regulation Questionnaire, the Flourishing Scale, and the Depression Anxiety Stress Scale. The results indicate that Curiosity Behaviors characteristically negatively predict existential vacuum. In addition, other variables, such as Flourishing, seem to be useful in explaining the relationships between these factors. Flourishing along with Curiosity increases a sense of Meaning in Life. Our results present evidence showing the importance of Curiosity Behaviors in coping with the existential vacuum.