Meaningful Memory in Acute Anorexia Nervosa Patients—Comparing Recall, Learning, and Recognition of Semantically Related and Semantically Unrelated Word Stimuli

Terhoeven, Valentin; Kallen, Ursula; Ingenerf, Katrin; Aschenbrenner, Steffen; Weisbrod, Matthias; Herzog, Wolfgang; Brockmeyer, Timo; Friederich, Hans‐Christoph; Nikendei, Christoph

doi:10.1002/erv.2496

Cited by 15 publications

(25 citation statements)

References 48 publications

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“…The effect that patients with AN were generally slower in their responses than healthy women replicates the result in Study 1 and might be attributable to reduced psychomotor speed, attention, and memory, associated with AN (Moser et al, 2003;Nikendei et al, 2011;Terhoeven et al, 2017). In Study 2, not only patients (as in Study 1) but all participants generally reacted faster to thin bodies than to normal-weight bodies, which might again mirror a greater salience of thin bodies for women (Friederich et al, 2007(Friederich et al, , 2010Vocks et al, 2010).…”

Section: Discussionsupporting

confidence: 62%

Approach and avoidance bias for thin‐ideal and normal‐weight body shapes in anorexia nervosa

Brockmeyer

Burdenski

Anderle

et al. 2020

Euro Eating Disorders Rev

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Objective The two studies aimed to examine implicit affective evaluations of thin‐ideal and normal‐weight body shapes in women with anorexia nervosa (AN), taking identification with body shapes into account. Method In study 1, approach–avoidance bias for thin‐ideal and normal‐weight bodies was assessed in 40 women with AN and 40 healthy women by using an Approach‐Avoidance Task and female avatar bodies with a standard face as stimuli. In study 2, 39 women with AN and 38 healthy women underwent a similar task but identification with bodies was manipulated by presenting bodies once with the participant's own face and once with another woman's face. Results In study 1, patients with AN did not differ from healthy participants in their automatic approach–avoidance tendencies towards thin‐ideal and normal‐weight bodies. In study 2, no definite approach bias for a thin self and no avoidance bias for thin other women or for a normal‐weight self were found. However, as compared to healthy women, those with AN showed a less positive implicit evaluation of thin other women, and an implicit preference for thin bodies depicted as themselves over thin bodies depicted as another woman. Conclusions The findings suggest that intra‐sexual competition for being slim is increased in AN.

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Section: Discussionsupporting

confidence: 62%

Approach and avoidance bias for thin‐ideal and normal‐weight body shapes in anorexia nervosa

Brockmeyer

Burdenski

Anderle

et al. 2020

Euro Eating Disorders Rev

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“…However, severe undernutrition in AN has been shown to be associated with (pseudo-) atrophic changes in grey matter 20, 21 , which may also affect performance on cognitive tasks 22 and brain function. Further, a large number of rather drastic changes in the endocrine system (e.g.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of altered feedback learning in women recovered from anorexia nervosa

Ritschel

Geisler

King

et al. 2017

Sci Rep

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Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dACC) activation in acutely ill patients (acAN) on lose-shift trials in a probabilistic reversal learning (PRL) task. However, undernutrition may modulate brain function. In attempt to disentangle trait from state factors, the current fMRI study investigated cognitive control in recovered patients (recAN). Thirty-one recAN and 31 healthy controls (HC) completed a PRL task during fMRI. Based on previous findings, we focused on hemodynamic responses during lose-shift behaviour and conducted supplementary functional connectivity analysis. RecAN showed elevated lose-shift behaviour relative to HC. On the neural level, recAN showed normal dACC responses, but increased activation in fronto-parietal control regions. A trend for increased coupling between frontal and parietal regions of interest was also evident in recAN. The current findings in recAN differ from those in our previous study in acAN. While aberrant dACC response to negative feedback may be a correlate of the underweight state in acAN, impaired behavioural adaptation and elevated activation of cognitive control regions in recAN is suggestive of altered neural efficiency.

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“…Similar to the present study, Buzzichelli et al (2018) found that adults with ED presented slower reaction times. However, other authors (Bentz, Jepsen, Kjaersdam Telleus, et al, 2017;Giannunzio et al, 2018;Terhoeven et al, 2017) emphasized the link between illness stage and processing speed: they concluded that patients in the acute phase present more severe impairments than recovered patients, noting that processing speed deficits frequently reverse after treatment. In the present study, it was found that processing speed difficulties were significantly related to a history of ED in most of the adjusted models, but the inclusion of the clinical covariates in the final model suggested that some of this relationship was accounted for by BMI, comorbid neurological and psychiatric conditions, and/or psychotropic medication.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, language (Overas et al, 2017;Spitoni et al, 2018) and orientation (Spitoni et al, 2018) frequently appear to be preserved. Meanwhile, results for measures of attention (Bentz, Jepsen, Kjaersdam Telleus, et al, 2017;Buzzichelli et al, 2018;Giannunzio et al, 2018;Spitoni et al, 2018;Terhoeven et al, 2017), processing speed (Bentz, Jepsen, Kjaersdam Telleus, et al, 2017;Buzzichelli et al, 2018;Giannunzio et al, 2018;Terhoeven et al, 2017), memory (Bentz, Jepsen, Kjaersdam Telleus, et al, 2017;Hamatani et al, 2018;Overas et al, 2017;Terhoeven et al, 2017) and verbal fluency (Spitoni et al, 2018;Zegarra-Most of the existing studies included small samples, and examined cognitive performance mostly in adolescents and young adults. The present research aimed to extend the evidence base, by including a larger sample, with older female participants, who were recruited by UK Biobank.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional study of cognitive function in women with a history of eating disorders in the UK Biobank cohort

M¹,

Cullen²

2020

Preprint

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Objective: The present study aimed to compare the cognitive functions of women who reported a history of eating disorders (ED) with women who did not report any such history. Within the group of women who reported a history of ED, it aimed to compare the cognitive functions of those who met anorexia nervosa body mass index (BMI) criteria at the time of assessment with those who did not meet such criteria. Method: The sample in this observational cross-sectional study belonged to the UK Biobank cohort, and consisted of 260,601 women in middle to older age, of whom 347 had a lifetime history of ED. Participants underwent sociodemographic, medical and psychological evaluation, and were assessed with four computerized cognitive tasks. Multiple regression analyses were conducted to take account of covariates. Results: Slower reaction time was found in those with an ED history: differences of small effect size were found across different levels of model adjustment (d=-.096 [95% CI -.201, .009] to -.150 [95% CI -.249, -.052]). Reasoning, visuospatial memory and prospective memory were not significantly different between those with and without a history of ED. A consistent pattern of results was not found when comparing the sub-sample of participants with ED split according to current BMI criteria. Discussion: The findings suggest that an ED history may correlate with slower processing speed in middle to older age, but this may be partly accounted for by clinical covariates. Further research in population-representative cohorts is required.

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Meaningful Memory in Acute Anorexia Nervosa Patients—Comparing Recall, Learning, and Recognition of Semantically Related and Semantically Unrelated Word Stimuli

Abstract: Semantics of stimuli do not have a better effect on memory recall in AN compared to CO. Impaired short-term versus long-term memory is discussed in relation to dysfunctional working memory in AN. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

Cited by 15 publications

References 48 publications

Approach and avoidance bias for thin‐ideal and normal‐weight body shapes in anorexia nervosa

Approach and avoidance bias for thin‐ideal and normal‐weight body shapes in anorexia nervosa

Neural correlates of altered feedback learning in women recovered from anorexia nervosa

Cross-sectional study of cognitive function in women with a history of eating disorders in the UK Biobank cohort

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