Measles and Subacute Sclerosing Panencephalitis

Kolar, Oldrich

doi:10.1016/s0140-6736(68)91719-4

Cited by 13 publications

(1 citation statement)

References 13 publications

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“…There is less unanimity in reports on cellular immunity (14). Some studies indicate a reduced cellular response (8,11,12,17,21); others indicate a normal response (13,16,19,20). We (9), among others (6,7), have attempted to develop an animal model to permit study of the immunological factors operative in the disease and in the viral infection.…”

Section: Received For Publication 2 November 1976mentioning

confidence: 99%

Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters

Cremer¹,

Hagens²,

Taylor³

et al. 1977

Infect Immun

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A study was done to investigate possible late central nervous system (CNS) complications of latent measles infection in hamsters. Signs of CNS disease, consisting of myoclonus and paralysis, occurred in some weanling hamsters inoculated intraperitoneally at 3 or 9 days of age with antithymocyte serum (ATS) and measles virus, but no late complications in adult life attributable to measles virus were seen. A single series of ATS injections plus an injection of measles virus resulted in sustained antibody formation postulated due to establishment of a latent viral infection, whereas similar treatment with normal rabbit serum plus virus caused no or minimal antibody response. The majority of hamsters receiving ATS as newborns and ATS plus virus as weanlings also did not produce antibody. This differential effect of ATS may be due to combined elimination of suppressor and helper cells in the latter ATS-treated group and of suppressor cells only in the former ATS-treated group. Cellular immunity could not be evaluated since lymphocytes from inoculated and uninoculated hamsters released equal and variable amounts of 5'Cr for both infected and noninfected labeled, allogeneic hamster target cells.The immunological implications in the pathogenesis of subacute sclerosing panencephalitis (SSPE) induced by latent measles virus infection of the central nervous system (CNS) are not clear at present. Antibody titers to measles virus in serum and cerebrospinal fluid at the time of recognized CNS disease are elevated by all criteria tested. There is less unanimity in reports on cellular immunity (14). Some studies indicate a reduced cellular response (8,11,12,17,21); others indicate a normal response (13,16,19,20). We (9), among others (6, 7), have attempted to develop an animal model to permit study of the immunological factors operative in the disease and in the viral infection. Antithymocyte serum (ATS) treatment of newborn hamsters rendered them susceptible to intraperitoneal (i.p.) injection of an SSPE strain of measles virus (Lec), a route of injection to which the untreated hamster is resistant. Such ATS-treated animals developed delayed overt signs of CNS involvement 3 weeks after virus inoculation. Only a small number ofthe treated hamsters survived, and with time these developed high titers of circulating antibody to measles virus, suggesting development ofa chronic, latent viral infection. Virus was isolated from the ATS-treated hamsters with CNS disease, but not from the survivors tested.

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Section: Received For Publication 2 November 1976mentioning

confidence: 99%

Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters

Cremer¹,

Hagens²,

Taylor³

et al. 1977

Infect Immun

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Inhibiting Factor: General Review

Karcher

1979

Humoral Immunity in Neurological Diseases

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Transfer factor therapy in patients with subacute sclerosing panencephalitis

et al. 1975

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Thirteen patients with subacute sclerosing panencephalitis (S.S.P.E.) at different stages of the disease were admitted for transfer factor treatment. The transfer factor was prepared from non-selected blood bank donors. The activity of the transfer factor was tested in patients with diseases other than S.S.P.E. and was found to be either clinically or immunologically active. Regardless of the number of transfer factor units applied a significant influence on the course of the disease was not apparant. The observed intermittant improvement of 3 patients was considered as spontaneous remission which is known to occur occasionally in S.S.P.E. The humoral and cellular immune response before and after transfer factor therapy did not reveal significant changes which could be correlated with transfer factor therapy.

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Measles and Subacute Sclerosing Panencephalitis

Cited by 13 publications

References 13 publications

Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters

Complications and immunological studies of measles virus infection in antithymocyte-treated hamsters

Inhibiting Factor: General Review

Transfer factor therapy in patients with subacute sclerosing panencephalitis

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