Measles Antibodies in Multiple Sclerosis.

Multiple sclerosis and exposure to solvents, ionizing radiation and animals.

“…The precise patho gene sis is unclear. Recent studies support the ideas that certain human leucocytlocu s A (HLA) haplotypes imply increased susceptibility to multiple sclerosis (1)(2)(3)(4)(5) and that infection s (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), for example , retro virus (16)(17)(18) , may play a role in the patho genesis. There are several observations regarding the associated occurrence of multipl e sclerosis with other autoimmune disorders ( 19), like myas then ia gravis (20), thyroid disease (2 1), and Sjogren ' s syndrome (22), but also with such clearly HLA-Iinked conditions as ankylosing spondylitis (23) and narcolepsy (24,25 ).…”

Cloned measles virus-specific T lymphocytes from a twin with multiple sclerosis.

“…Studies with a panel of HLA-typed irradiated mononuclear cells indicate that antigen is presented to the clone in the context ofa gene product linked to, but not identical with, HLA-DRw2. The clone produces interleukin 2 and has surface determinants recognized by OKT-3, OKT-4, and anti-HLA-DR monoclonal antibodies, but not by . It thus appears to belong to the helper/inducer subpopulation of T lymphocytes.…”

“…Since the 1962 report of Adams and Imagawa demonstrating increased anti-measles antibody titers in MS patients (2), numerous efforts have been made to detect an aberrant immune response to this virus in these patients (reviewed in ref.…”

Examination of Eight Cases of Multiple Sclerosis and 56 Neurological and Non-neurological Controls for Genomic Sequences of Measles Virus, Canine Distemper Virus, Simian Virus 5 and Rubella Virus

“…Epidemiological and serological studies have suggested the involvement of a number of different enveloped RNA viruses in MS, including measles virus (MV), canine distemper virus (CDV), simian virus 5 (SV5) and rubella virus (Haire et al, 1973;Norrby et al, 1974;Haire, 1977;Meurman et al, 1977;Cook et al, 1978;Goswami et al, 1987). Measles virus is still a prime candidate on the basis of evidence from serological studies of MS patients and controls (Adams & Imagawa, 1962;Haire et al, 1973 ;Norrby et al, 1974;Haire, 1977;Salmi et al, 1972Salmi et al, , 1983Felgenhauer et al, 1985) whereas data suggesting the involvement of SV5 or CDV are either not reproducible or are non-specific for the virus in question (Madden et al, 1981 ;Halle et aL, 1982;Brankin et al, 1989).…”