Measles antibodies, ?-? light chain distribution and immunoglobulins in serum, cerebrospinal fluid and brain of a patient affected with multiple sclerosis

Abstract

The serum, cerebrospinal (CSF) and brain of a patient (NAG) affected with multiple sclerosis (MS) were examined for measles antibodies with CF and HI techniques, and the kappa-lambda light chain ratios of all samples available were evaluated, kappa-lambda populations of the matched serum, CSF and brain specimens were all lambda-predominant and in agreement with each other; the light chain distribution f the brain specimens confirmed previous findings [3]. Only the serum immunoglobulins showed significant measles antibody titers, but slightly increased measles antibody titers were also observed in ventricular plaques. The amount of immunoglobulin G (IgG) synthesized per day by the central nervous system (CNS) was estimated. The IgG synthesis in CNS NAG (11.6 mg/day) was above the upper limit of the normal range (3.3 mg/day), but apparently there was no positive correlation between the intracerebral IgG synthesis and specific anti-measles IgG.

Measles antibodies, anti-proteinase and plasminogen distribution in serum and plasma from patients affected with multiple sclerosis and patients affected with non-neurological diseases

“…As far äs the measles antibody activity is concerned, even if the general increase in measles antibody titers is more elevated in multiple sclerosis, the finding that elevated titers do not solely appear in multiple sclerosis, but in non-neurological diseases äs well, adds more evidenee in favour of the hypothesis that increase of viral antibody titers may be the result of non specific Stimulation (19), related in some unknown way to the disease process in the CNS; äs far äs multiple sclerosis is concerned, it also confirms our earlier results (20,21). Poskitt et al (22) demonstrated that immunization of single lymphnodes with various antigens led to the appearance of cells in the afferent lymph that secreted antibody specific for antigen and for a number of unrelated, non-crossreacting antigens.…”

Measles Antibodies, Anti-Proteinase and Plasminogen Distribution in Serum and Plasma from Patients Affected with Multiple Sclerosis and Patients Affected with Non-Neurological Diseases

“…As far äs the measles antibody activity is concerned, even if the general increase in measles antibody titers is more elevated in multiple sclerosis, the finding that elevated titers do not solely appear in multiple sclerosis, but in non-neurological diseases äs well, adds more evidenee in favour of the hypothesis that increase of viral antibody titers may be the result of non specific Stimulation (19), related in some unknown way to the disease process in the CNS; äs far äs multiple sclerosis is concerned, it also confirms our earlier results (20,21). unrelated, non-crossreacting antigens.…”

“…response to measles virus. c) finally, in a paper on measles antibodies, l ight chain distribution and imriiünoglobulins in serum, CSF and brain of a patient affeeted with multiple scierosis (21), the data assembled did not add up to convincing arguments for a measles vifüs^etiology. We con·?…”