Measles antibody levels among vaccinated and unvaccinated children 6–59 months of age in the Democratic Republic of the Congo, 2013–2014

Ashbaugh, Hayley; Cherry, James D.; Hoff, Nicole A.; Doshi, Reena H.; Alfonso, Vivian H.; Gadoth, Adva; Mukadi, Patrick; Higgins, Stephen G.; Budd, Roger; Randall, Christina; Mwamba, Guillaume Ngoie; Okitolonda-Wemakoy, Emile; Muyembe-Tamfum, Jean Jacques; Gerber, Sue; Rimoin, Anne W.

doi:10.1016/j.vaccine.2019.09.047

Cited by 8 publications

(14 citation statements)

References 29 publications

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“…In addition, it must be taken into account that the current vaccination schedule during the first year of life of older patients under study could differ from the current one given to younger participants, modifying the protection against some of the vaccine pathogens. Our data revealed similar immunization rates to measles (64%) in the study paediatric population from Kinshasa during 2016–2018 than in other paediatric cohorts in the DRC during 2013–2014 39 , being slightly higher than the vaccination coverage after the first and single dose of measles vaccine administered at 9 months of age reported by the WHO in that country (57%) 9 .…”

Section: Discussionsupporting

confidence: 76%

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Rodriguez-Galet

Rubio-Garrido

Valadés-Alcaraz

et al. 2022

Sci Rep

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Child vaccination reduces infant mortality rates. HIV-infected children present higher risk of diseases than non-infected. We report the protection coverage rates for 6 vaccine-preventable diseases in a paediatric population from the Democratic Republic of the Congo (DRC) and the impact of HIV infection, providing the first data on the validity of dried blood samples (DBS) to monitor the immune protection. During 2016–2018 DBS from 143 children/adolescents were collected in Kinshasa (DRC), being 52 HIV-infected. Forty-two had a paired plasma sample. Protective IgG was quantified (VirClia-IgG,VIRCELL) to obtain the optimal cut-off in IgG detection in DBS. ROC curves were generated with R software and statistical analyses with Stata. Protective IgG levels varied across pathogens, not reaching herd immunity. HIV-infected presented lower vaccine protection than uninfected for all analyzed pathogens, except rubella, with statistically significant differences for measles (30.8% vs. 53.8%; p = 0.008) and tetanus (3.8% vs. 22%; p = 0.0034). New cut-offs were calculated when using DBS to improve test performance. We reinforce the necessity to increase pediatric vaccination coverage in Kinshasa, especially in HIV seropositive, with less capacity to maintain adequate antibody levels. DBS were useful to monitor vaccination coverage in seroprevalence studies in resource-limited settings, after optimizing the cut-off value for each pathogen.

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Section: Discussionsupporting

confidence: 76%

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Rodriguez-Galet

Rubio-Garrido

Valadés-Alcaraz

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In addition, it must be taken into account that the current vaccination schedule during the rst year of life of older patients under study could differ from the current one given to younger participants, modifying the protection against some of the vaccine pathogens. Our data revealed similar immunization rates to measles (64%) in the study paediatric population from Kinshasa during 2016-2018 than in other paediatric cohorts in the DRC during 2013-2014 [29], being slightly higher than the vaccination coverage after the rst and single dose of measles vaccine administered at 9 months of age reported by the WHO in that country (57%) [8].…”

Section: Discussionsupporting

confidence: 68%

Protection to Six Vaccinable Pathogens in Paired Plasma/DBS and HIV Impact in Infected and Uninfected Children From Kinshasa

Rodríguez-Galet

Rubio-Garrido

Ana

et al. 2021

Preprint

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Child vaccination reduces infant mortality rates. HIV-infected children present higher risk of diseases than non-infected. We report the protection coverage rates to 6 vaccine-preventable diseases in a paediatric population from the Democratic Republic of the Congo (DRC) and the impact of HIV infection, providing the first data on the validity of dried blood samples (DBS) to monitor the immune protection. During 2016-2018 DBS from 143 children/adolescents were collected in Kinshasa (DRC), being 52 HIV-infected. Forty-two had a paired plasma sample. Protective IgG was quantified (VirClia®IgG,Vircell) to obtain the optimal cut-off in IgG detection in DBS. ROC curves were generated with R software and statistical analyses with Stata. Protective IgG levels varied across pathogens, not reaching the herd immunity. HIV-infected presented lower vaccine protection than uninfected for all analysed pathogens, except rubella, with statistically significant differences for measles (30.8% vs. 53.8%;p=0.008) and tetanus (3.8% vs. 22%;p=0.004). New cut-offs were calculated when using DBS to improve test performance. We reinforce the necessity to increase pediatric vaccination coverage in Kinshasa, specially in HIV seropositive, with less capacity to maintain adequate antibody levels. DBS were useful to monitor vaccination coverage in seroprevalence studies in resource-limited settings, after optimizing the cut-off value for each pathogen.

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“…Seropositive control and low vaccine efficiency are multifaceted and depend on the vaccination program's capability, vaccine potency, and host characteristics (particularly the immune system as a consequence of age and nutritional status) [27]. Vaccination rates were higher in boys than in girls, but not by a significant statistically.…”

Section: Discussionmentioning

confidence: 99%

The Role of Sex, Ethnicity, Age, and Nutritional Status in the Seropositivity of the Measles Vaccine

Nurlatifah

Barlıanto

Wiyasa

et al. 2021

Open Access Maced J Med Sci

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AIM: This study investigates the relationship between sex, ethnicity, age, nutritional status with the seropositivity of the Edmonston-Zagreb vaccine in children. METHODS: A cross sectional, observational study was conducted. A total of 45 children were differentiated based on sex, ethnicity, age, and nutritional status when they received the Edmonston-Zagreb measle vaccine for the first time. Flow cytometry was used to look at differences in antibody status as well as populations of CD-4 and CD-8 cells that release IFN- γ. RESULTS: We found no significant differences in antibody levels or CD-4 and CD-8 cell populations that secrete IFN- γ between boys and girls (p > 0.05). Besides, similar results were also confirmed in comparisons between Javanese and Sundanese ethnic groups, 9 months versus more than 9 months of age, or normal versus low body mass index (p > 0.05). CONCLUSIONS: We conclude that sex, race, age, and nutritional status had no effect on immune response to vaccination. As a result, there was no barrier to seroconversion and optimal immunological performance in the children in this trial who received the Edmonston-Zagreb measles vaccination.

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Measles antibody levels among vaccinated and unvaccinated children 6–59 months of age in the Democratic Republic of the Congo, 2013–2014

Cited by 8 publications

References 29 publications

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Protection to Six Vaccinable Pathogens in Paired Plasma/DBS and HIV Impact in Infected and Uninfected Children From Kinshasa

The Role of Sex, Ethnicity, Age, and Nutritional Status in the Seropositivity of the Measles Vaccine

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Measles antibody levels among vaccinated and unvaccinated children 6–59 months of age in the Democratic Republic of the Congo, 2013–2014

Cited by 8 publications

References 29 publications

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Immune surveillance for six vaccinable pathogens using paired plasma and dried blood spots in HIV infected and uninfected children in Kinshasa

Protection to Six Vaccinable Pathogens in Paired Plasma/DBS and HIV Impact in Infected and Uninfected Children From Kinshasa

The Role of Sex, Ethnicity, Age, and Nutritional Status in the Seropositivity of the Measles Vaccine

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Product

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Measles antibody levels among vaccinated and unvaccinated children 6–59 months of age in the Democratic Republic of the Congo, 2013–2014