Measles epidemic from 1951 to 2012 and vaccine effectiveness in Guangzhou, Southern China

Yang, Zhicong; Xu, Jianxiong; Wang, Ming; Di, Biao; Tan, Hongbing; He, Qing; Cai, Yong Shun; Liang, Jing; Hu, Wensui; Dong, Zhiqiang; Yang, Yunqing; Fu, Chuanxi

doi:10.4161/hv.27895

Cited by 10 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 24 In today’s accelerated measles elimination stage, morbidity continues to decline 24 and the age distribution of measles has shifted to non-target populations for measles vaccination (children <8 months of age or adults). 24 , 25 The waning of maternal antibody in infants will be one of the biggest obstacles to eliminating measles worldwide.…”

Section: Discussionmentioning

confidence: 99%

Waning of maternal antibody against measles virus in Shufu, China

Fan

Xue³

et al. 2022

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

Background: As measles vaccination coverage has increased, measles infection has shifted to the population of infants. We conducted a follow-up seroepidemiological study among mothers and their infants to evaluate measles seroprevalence and the persistence of maternal measles antibody in Shufu, Kashgar from 2018 to 2020. Methods: Maternal venous blood and cord blood was obtained among mothers and their infants at 0, 3, 5, 8, 9, and 12 months of age. An enzyme-linked immunosorbent assay was used for quantitative measurement of measles antibodies. We analyzed the correlation between maternal and neonatal measles antibodies, and antibodies persistence after infants were born. Results: The overall neonatal maternal ratio was 2.38 (95%CI: 2.05–2.71). The measles antibodies for mothers and newborns were 438.93 IU/mL (95%CI: 409.47–470.51 IU/mL) and 440.10 IU/mL (95%CI: 410.82–471.48 IU/mL), respectively. Neonatal measles antibodies were dropping after birth and then beginning to increase starting at 8 months of age. Conclusions: Infant measles antibody levels progressively declined after birth regardless of maternal measles antibody levels. Efforts should be carried out to eliminate measles.

show abstract

Section: Discussionmentioning

confidence: 99%

Waning of maternal antibody against measles virus in Shufu, China

Fan

Xue³

et al. 2022

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Here we estimate that R 0 for Beijing, Guangzhou, and Shandong—two major cities and one province in China—was around 16, and stayed at similar levels in the pre- and post-vaccine eras (Fig 5A). Based on our estimate, to eliminate measles in these locations, a minimal population herd immunity of 93.8%, or with a vaccine efficacy (VE) of 95% [30], a minimal vaccine coverage of 98.7% [ V T = (1–1/ R 0 ) ÷ VE = (1–1/16) ÷ 0.95] is needed. Note the latter, more conservative estimate is above the targeted 95% vaccination threshold [1].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of measles epidemics in China (1951-2004) and implications for elimination: A case study of three key locations

Yang

Shaman

2019

PLoS Comput Biol

View full text Add to dashboard Cite

Measles is a highly infectious, severe viral disease. The disease is targeted for global eradication; however, this result has proven challenging. In China, where countrywide vaccination coverage for the last decade has been above 95% (the threshold for measles elimination), measles continues to cause large epidemics. To diagnose factors contributing to the persistency of measles, here we develop a model-inference system to infer measles transmission dynamics in China. The model-inference system uses demographic and vaccination data for each year as model inputs to directly account for changing population dynamics (including births, deaths, migrations, and vaccination). In addition, it simultaneously estimates unobserved model variables and parameters based on incidence data. When fitted to yearly incidence data for the entire population, it is able to accurately estimate independent, out-of-sample age-specific incidence. Using this validated model-inference system, we are thus able to estimate epidemiological and demographical characteristics key to measles transmission during 1951–2004 for three key locations in China, including its capital Beijing. These characteristics include age-specific population susceptibility and incidence rates, the basic reproductive number ( R 0 ), reporting rate, population mixing intensity, and amplitude of seasonality. Key differences among the three sites reveal population and epidemiological characteristics crucial for understanding the current persistence of measles epidemics in China. We also discuss the implications our findings have for future elimination strategies.

show abstract

“…This may have been a cause of outbreak in 2009 and 2010 in Bandar Abbas. It is shown that two doses of measles vaccination are more effective than a single dose vaccination ( 18 ) and timely routine vaccination plays an important role in measles eradication ( 19 ). However, the fewer cases of measles in 2011 and 2013, is due to vaccination of the relatives and close contacts of definite cases discovered by health surveillance system.…”

Section: Discussionmentioning

confidence: 99%

A report of outbreaks of measles on the southern coast of Iran from 2009 to 2015

et al. 2017

View full text Add to dashboard Cite

IntroductionImmunogenicity assessment figures of the measles vaccine is approximately 90%, and decreases over time. Therefore, the immunity level of measles vaccine is variable which can result in outbreaks of measles in a population. The aim of current study was to report the outbreaks of measles in Hormozgan province from 2009 to 2015.MethodsThis cross-sectional study was carried out in Hormozgan Province on the southern coast of Iran. The documented data of all cases suspected of measles are included in this study. We used a checklist including gender, age, area, place of residence, contact history, and vaccination status to extract required data. Data was analyzed using IBM SPSS statistics software version 21.0.ResultsEight hundred fifty-one suspicious cases of measles were determined from 2006 to 2015. Of those, 135 infected cases were reported. Among patients, 49% were male, 79% were Iranian, 18% were Afghans, and 3 % were Indians or Pakistanis. Also, 31% of cases were reported from Bandar Abbas, 25% were reported from Minab, 18% from Qeshm, 17 % from Jask and other cases were reported from other areas of the Hormozgan Province. Thirty percent of the cases were reported from urban areas.ConclusionA high percentage of cases with measles in rural areas were reported in the areas which were covered by complete vaccination. This shows interruption of cold continuum. Also, increasing the number of under one-years-old cases reported, could be due to poor nutritional status of the children and insufficient immunization of mothers. Further studies are required for identifying the causes of cold continuum interruption. Further studies are required for the assessment of immunization in children and mothers and various vaccination protocols.

show abstract

Measles epidemic from 1951 to 2012 and vaccine effectiveness in Guangzhou, Southern China

Cited by 10 publications

References 18 publications

Waning of maternal antibody against measles virus in Shufu, China

Waning of maternal antibody against measles virus in Shufu, China

Characteristics of measles epidemics in China (1951-2004) and implications for elimination: A case study of three key locations

A report of outbreaks of measles on the southern coast of Iran from 2009 to 2015

Contact Info

Product

Resources

About