Measles Virus Persistence in Human Lymphocytes: A Role for Virus-induced Interferon

Jacobson, Steven; McFarland, Henry F.

doi:10.1099/0022-1317-63-2-351

Cited by 34 publications

(22 citation statements)

References 18 publications

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“…Thus, rabies virus-infected K-104 cells might gradually enter the antiviral state before the beginning of vigorous virus production. Similar findings of the role of endogenous interferon in some other virus-host cell systems have been reported in which the application of anti-interferon antibody treatment was included (Vil~ek et al, 1977;Nagai et al, 1981;Jacobson & McFarland, 1982;Linnavuori & Hovi, 1983).…”

Section: Discussionsupporting

confidence: 75%

Comparative Studies of Rabies and Sindbis Virus Replication in Human Neuroblastoma (SYM-I) Cells that Can Produce Interferon

Honda

Kawai

Matsumoto

1984

Journal of General Virology

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SUMMARYK-104 cells, a cloned cell line derived from a human neuroblastoma (SYM-I), were induced by rabies HEP-Flury virus to release large amounts of interferon, and the resulting antiviral activity significantly suppressed the rabies virus replication. The role of endogenous interferon was confirmed by treatment with anti-interferon antibody which increased the yield of progeny virus. The virus yield in the second undiluted passage through K-104 cells was much less than that in the first passage, because of the antiviral state initiated by brief contact of interferon present in the virus inoculum with cells during the short period of virus adsorption. When the m.o.i, was relatively low, as in the third undiluted passage, the effect of interferon present in the inoculum was enhanced and most of the infected cells survived but were shown to be in a state of persistent infection. Defective interfering (DI) particles did not accumulate rapidly during these three undiluted passages. When Sindbis virus was used for infection, the endogenous interferon system of K-104 cells was not activated during 12 undiluted passages. However, on the 12th passage, the yield began to decline due to the generation and accumulation of DI particles.

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Section: Discussionsupporting

confidence: 75%

Comparative Studies of Rabies and Sindbis Virus Replication in Human Neuroblastoma (SYM-I) Cells that Can Produce Interferon

Honda

Kawai

Matsumoto

1984

Journal of General Virology

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“…In addition to this, mumps virus infection can lead to a chronic infection of the central nervous system. Though the mechanisms and maintenance of these persistent infections are still obscure, various reports have been made and it has been suggested that such persistent infection is the result of the appearance of virus mutants or interferon (IFN) (Andzhaparidze et al, 1982;Carter et at., 1983;Jacobson & McFarland, 1982;Truant & Therefore, the change in activity of such antiviral systems caused by virus infection may be correlated with persistent infection. We have studied the fluctuation of oligo-2',5'-adenylate synthetase (2-5AS) activity in K562 cells acutely and persistently infected with mumps or measles virus to investigate this point.…”

Section: Discussionmentioning

confidence: 99%

Oligo-2',5'-adenylate Synthetase Activity in K562 Cell Lines Persistently Infected with Measles or Mumps Virus

Fujii¹,

Oguma²,

Kimura³

et al. 1988

Journal of General Virology

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“…Among the many factors claimed to be involved in the establishment and maintenance of persistent virus infections are the interferons (IFNs), either as mediators of persistence (Jacobson & McFarland, 1982) or because of lack of IFN production (Ikeda et al, 1986). One of the unresolved problems in animal virology is the pathogenesis of mucosal disease in cattle caused by bovine viral diarrhoea virus (BVDV).…”

mentioning

confidence: 99%

Influence of Interferons 11 and and of Tumour Necrosis Factor on Persistent Infection with Bovine Viral Diarrhoea Virus in Vitro

Ohmann¹,

Babiuk

1988

Journal of General Virology

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SUMMARYNon-cytopathic strains of bovine viral diarrhoea virus (BVDV) readily establish persistent infections in cells of bovine origin. The involvement of endogenous interferon (IFN) on the maintenance of the infection level, as well as the effect of exogenous IFN and tumour necrosis factor alpha (TNF-~), was studied. Although exogenous IFN suppressed the spread and replication of virus, it did not cure the infection, even when continuously present over many cell passages. TNF-~ alone had no antiviral effect in this system. However, both TNF-~ and IFN enhanced the cytopathic effect of cytopathic BVDV, and induced a BVDV-like cytopathic effect in cells infected with non-cytopathic BVDV. These data are discussed with regard to possible mechanisms of pathogenesis during fatal BVDV disease in cattle.

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Measles Virus Persistence in Human Lymphocytes: A Role for Virus-induced Interferon

Cited by 34 publications

References 18 publications

Comparative Studies of Rabies and Sindbis Virus Replication in Human Neuroblastoma (SYM-I) Cells that Can Produce Interferon

Comparative Studies of Rabies and Sindbis Virus Replication in Human Neuroblastoma (SYM-I) Cells that Can Produce Interferon

Oligo-2',5'-adenylate Synthetase Activity in K562 Cell Lines Persistently Infected with Measles or Mumps Virus

Influence of Interferons 11 and and of Tumour Necrosis Factor on Persistent Infection with Bovine Viral Diarrhoea Virus in Vitro

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