Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells

Bhattacharjee, Sankhajit; Jaiswal, Rishi Kumar

doi:10.1007/s12038-018-9834-6

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…The appearance of these two responses is not synchronous during PRV infection, and the underlying interactions between them have not been well-characterized. For a coronavirus and a paramyxovirus, it has been suggested that preventing apoptosis at the early stage of infection contributes to viral replication and results in a higher yield of virus ( 27 , 28 ). We found that inhibition of apoptosis decreased the replication efficiency of PRV in PK-15 cells and resulted in an up-regulation of the autophagy level.…”

Section: Discussionmentioning

confidence: 99%

The relationship between autophagy and apoptosis during pseudorabies virus infection

et al. 2022

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Both autophagy and apoptosis are mechanisms that maintain homeostasis in cells and that play essential roles in viral infections. Previous studies have demonstrated that autophagy and apoptosis pathways occurred with complex relationships in virus-infected cells. However, the regulation between these two processes in Pseudorabies virus (PRV) infection remains unclear. In the present study, we demonstrated that activated autophagy was induced at the early stage of PRV infection and that apoptosis was induced at the late stage of infection. Autophagy induction inhibited apoptosis and decreased viral replication, and autophagy inhibition promoted apoptosis and increased viral replication. We also found that viral infection resulted in an increase in the production of reactive oxygen species (ROS) and activation of apoptosis in autophagy-impaired cells, suggesting that ROS may participate in the cross-talk between autophagy and apoptosis in PRV-infected cells. Our studies provide possible molecular mechanisms for the cross-talk between apoptosis and autophagy induced by PRV infection in porcine cells. This suggests that these two cell death processes should be considered as the same continuum rather than as completely separate processes.

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Section: Discussionmentioning

confidence: 99%

The relationship between autophagy and apoptosis during pseudorabies virus infection

et al. 2022

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“…Finally, this iron homeostasis regulation assists host cells in avoiding apoptosis and promotes the viral production of HPIV2 (Ohta et al, 2021). In addition to the V proteins discussed above, the P protein of MeV exhibits anti-apoptotic function and enhances the viral production in Hela cells (Bhattacharjee et al, 2019).…”

Section: Accessory Proteins Inhibit the Apoptosis Autophagy And Stress Granules Apoptosismentioning

confidence: 97%

Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins

Wang

Duan

et al. 2022

Front. Microbiol.

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For efficient replication, viruses have developed multiple strategies to evade host antiviral innate immunity. Paramyxoviruses are a large family of enveloped RNA viruses that comprises diverse human and animal pathogens which jeopardize global public health and the economy. The accessory proteins expressed from the P gene by RNA editing or overlapping open reading frames (ORFs) are major viral immune evasion factors antagonizing type I interferon (IFN-I) production and other antiviral innate immune responses. However, the antagonistic mechanisms against antiviral innate immunity by accessory proteins differ among viruses. Here, we summarize the current understandings of immune evasion mechanisms by paramyxovirus accessory proteins, specifically how accessory proteins directly or indirectly target the adaptors in the antiviral innate immune signaling pathway to facilitate virus replication. Additionally, some cellular responses, which are also involved in viral replication, will be briefly summarized.

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“…These proteins can be used against cancer cells by triggering apoptosis and inducing antitumor immunity. The roles of paramyxovirus proteins, including HN and M (NDV) [17,35,36], N and P (measles virus) [13,37], M (PPRV) [12], and V (mumps virus) [33], in apoptosis or survival of transformed cells have been examined. Although the oncolytic activity of the mumps virus has been previously validated in some studies [18,30,[38][39][40], it has been shown that the mumps virus V protein modulates apoptosis in cervical adenocarcinoma cancer cells [16].…”

Section: Plos Onementioning

confidence: 99%

The power of mumps virus: Matrix protein activates apoptotic pathways in human colorectal cell lines

Morovati,

Mohammadi,

Masoudi

et al. 2023

PLoS ONE

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New therapeutic approaches can significantly impact the control of colorectal cancer (CRC), which is increasing worldwide. In this study, we investigated the potential of targeting viral proteins to combat cancer cells. Specifically, we examined the anticancer potential of the matrix (M) protein of the mumps virus Hoshino strain in SW480 CRC cell lines. To begin, we individually transfected SW480 cells with pcDNA3 plasmids containing the mumps virus M gene. We then investigated the percentage of cell death, caspase activity, and the expression levels of genes involved in apoptosis pathways. Following this, we performed bioinformatics analysis on the M protein to identify any similarities with Bcl-2 family members and their viral homologs. Our diagnostic methods showed that treatment with the mumps M protein induced apoptosis and upregulated the expression and activity of pro-apoptotic proteins in SW480 CRC cells compared to the control and vector groups. Based on our bioinformatics studies, we proposed that the BH3 motif in the M protein may trigger apoptosis in CRC cells by interacting with cellular Bax. Overall, our study showed for the first time that the mumps virus M protein could be considered as a targeted treatment for CRC by inducing apoptotic pathways.

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Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells

Cited by 5 publications

References 33 publications

The relationship between autophagy and apoptosis during pseudorabies virus infection

The relationship between autophagy and apoptosis during pseudorabies virus infection

Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins

The power of mumps virus: Matrix protein activates apoptotic pathways in human colorectal cell lines

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