Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion.

Harrowe, Greg; Mitsuhashi, Masato; Payan, Donald G.

doi:10.1172/jci114571

Cited by 33 publications

(18 citation statements)

References 20 publications

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“…Measles virus (MV) encodes the fusion protein (F), which mediates cell fusion and the intercellular spread of the virus and is homologous to the carboxy terminus of the SP (Harrowe et al 1990). In addition, the oligopeptide Z-D-Phe-L-Phe-Gly (Table 2), a homologous antagonist (peptide NK-1 receptor antagonist) to F and SP, inhibits MV fusion with target cells.…”

Section: Measles Virusmentioning

confidence: 99%

“…These observations raise the question of whether MV uses the NK-1 receptor during a specific phase of its infective cycle. Moreover, bound MV and SP have been shown to displace each other from target cells reciprocally (Harrowe et al 1990). In addition, anti-SP antisera inhibit the cellto-cell spread of MV, blocking MV fusion with target cells.…”

Section: Measles Virusmentioning

confidence: 99%

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Involvement of substance P and the NK-1 receptor in human pathology

2014

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The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also present in cells not belonging to the nervous system (immune cells, liver, lung, placenta, etc.). SP is located in all body fluids, such as blood, cerebrospinal fluid, breast milk, etc. i.e. it is ubiquitous in human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. SP has been also implicated in pain, inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infection (e.g., HIV infection) and it plays an important role in cancer (e.g., tumor cell proliferation, antiapoptotic effects in tumor cells, angiogenesis, migration of tumor cells for invasion, infiltration and metastasis). This means that the SP/NK-1 receptor system is involved in the molecular bases of many human pathologies. Thus, knowledge of this system is the key for a better understanding and hence a better management of many human diseases. In this review, we update the involvement of the SP/NK-1 receptor system in the physiopathology of the above-mentioned pathologies and we suggest valuable future therapeutic interventions involving the use of NK-1 receptor antagonists, particularly in the treatment of emesis, depression, cancer, neural degeneration, inflammatory bowel disease, viral infection and pruritus, in which that system is upregulated.

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Section: Measles Virusmentioning

confidence: 99%

Section: Measles Virusmentioning

confidence: 99%

Involvement of substance P and the NK-1 receptor in human pathology

2014

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“…Notably, SPR apparently redistributes in T cells toward the VS, and, given its ability to support MV entry into T cells and cell-to-cell transmission in neurons, may play an active role in MV uptake (Fig. 6) (19,20,30). The similarity of the internal substance P FFG sequence with FIP and the N-terminal hydrophobic MV F1 fusion domain suggested it might, by interacting with the MV F protein, enhance fusion, which may well affect the sensitivity of this process to neutralizing antibodies (Fig.…”

Section: Discussionmentioning

confidence: 99%

Measles Virus Transmission from Dendritic Cells to T Cells: Formation of Synapse-Like Interfaces Concentrating Viral and Cellular Components

Koethe

Avota

Schneider‐Schaulies

2012

J Virol

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Transmission of measles virus (MV) to T cells by its early CD150+target cells is considered to be crucial for viral dissemination within the hematopoietic compartment. Using cocultures involving monocyte-derived dendritic cells (DCs) and T cells, we now show that T cells acquire MV most efficiently fromcis-infected DCs rather than DCs having trapped MV (trans-infection). Transmission involves interactions of the viral glycoprotein H with its receptor CD150 and is therefore more efficient to preactivated T cells. In addition to rare association with actin-rich filopodial structures, the formation of contact interfaces consistent with that of virological synapses (VS) was observed where viral proteins accumulated and CD150 was redistributed in an actin-dependent manner. In addition to these molecules, activated LFA-1, DC-SIGN, CD81, and phosphorylated ezrin-radixin-moesin proteins, which also mark the HIV VS, redistributed toward the MV VS. Most interestingly, moesin and substance P receptor, both implicated earlier in assisting MV entry or cell-to-cell transmission, also partitioned to the transmission structure. Altogether, the MV VS shares important similarities to the HIV VS in concentrating cellular components potentially regulating actin dynamics, conjugate stability, and membrane fusion as required for efficient entry of MV into target T cells.

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“…The presence of MV nucleocapsids and MV Hemagglutinin in the neuronal axonal processes suggest that MV spreads transneuronally (Rima & Duprex, 2005 for a review). In 1990 D.Payan and collaborators found that a lymphoblastoid cell line that constitutively express the neuropeptide, (substance P) receptor, neurokinin-1, facilitate MV fusion (Harrowe et al, 1990). M. Billeter and cols in slice cultures demonstrated neuron-to-neuron polarized spread of a recombinant autoflurescent MV (Ehrengruber et al, 2002).…”

Section: Sspe Onset Clinical Course and Pathogenesismentioning

confidence: 99%