Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study

McGibbon, Chris A.; Trahan, Carol

doi:10.1016/s1063-4584(03)00078-5

Cited by 69 publications

(57 citation statements)

References 37 publications

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“…Lesions found and staged with arthroscopy are more likely to be detected using MRI (due to larger size) than those found using histology. The relatively lower sensitivity to lesions in our study might also be in part due to our exclusive use of sagittal MRI images for detection and evaluation of cartilage lesions, whereas others have used multiple planes to locate and stage abnormalities [8,26,27].…”

Section: Discussionmentioning

confidence: 75%

“…Loss of cartilage thickness was predicted with 72% sensitivity and 69% specificity; however, sensitivity for cartilage surface integrity was lower and specificity was higher (69% and 74%, respectively). While others have assessed the diagnostic performance of MRI for cartilage lesions using histology [25][26][27][28][29][30], few [9,10,22] have determined the diagnostic performance of FSE sequences with comparison to histology. Our outcomes are comparable to some, but slightly lower than the findings of other investigators in sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

“…In SPGR images, cartilage is only bright, and signal abnormalities are generally not observed, whereas iw FSE sequences do demonstrate changes in cartilage signal, believed to be caused by increased intracartilaginous water content as a result of loss of proteoglycans in OA [36], which, however, is not supported by the findings of our study. Further, SPGR imaging does not provide cartilagefluid contrast, lowering its ability to delineate small cartilage defects and surface lesions as compared to FSE imaging; in a study by McGibbon et al [27], for example, SPGR imaging at 1.5 T significantly under-predicted the actual depth of defects in cartilage, when compared to histology. However, the FSE sequence suffers from limited through-plane resolution relative to SPGR imaging.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference

et al. 2008

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The purpose of this study was (1) to evaluate the sensitivity, specificity and accuracy of sagittal in vivo 3-T intermediate-weighted fast spin-echo (iwFSE) sequences in the assessment of knee cartilage pathologies using histology as the reference standard in patients undergoing total knee replacement, and (2) to correlate MR imaging findings typically associated with osteoarthritis such as bone marrow edema pattern (BMEP) and cartilage swelling with histological findings. Tibial plateaus and femoral condyles of eight knees of seven patients were resected during surgery, and sagittal histological sections were prepared for histology. Preoperative MRI findings were compared to the corresponding region in histological sections for thickness, surface integrity and signal pattern of cartilage, and histological findings in areas of BMEP and swelling were documented. The overall sensitivity, specificity and accuracy were 72%, 69% and 70% for thickness, 69%, 74% and 73% for surface and 36%, 62% and 45% for intracartilaginous signal pattern. For all cases of BMEP on MRI subchondral © European Society of Radiology 2008Correspondence to: Thomas M. Link. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript ingrowth of fibrovascular tissue and increased bone remodeling were observed. MRI using fatsaturated iwFSE sequences showed good performance in assessing cartilage thickness and surface lesions, while signal changes of cartilage were not suited to characterize the severity of cartilage degeneration as validated by histology. NIH Public AccessAuthor Manuscript Eur Radiol. Author manuscript; available in PMC 2010 March 15.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference

et al. 2008

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“…McGibbon and Trahan (115) found the mean difference between measured and actual artificial cartilage defect diameters in the human knee cartilage to be <0.1 mm, whereas the lesion depth was underestimated in MRI by >0.4 mm. Graichen et al (128) observed an overestimation of the true size of artificial cartilage defects in the human knee, which decreased from 42% in 3 mm defects to 4% in 8 mm defects.…”

Section: Technical Accuracy and Precision Of Measurementsmentioning

confidence: 99%

“…In order to track local/regional thickness changes over time, techniques for displaying regional thickness patterns have been developed (91,94,100,(113)(114)(115). These techniques have also been applied to the detection of cartilage lesions, but only a limited number of thickness intervals can be displayed with a limited number of color codes or gray levels.…”

Section: Image Analysis Techniquesmentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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Natural History of Knee Cartilage Defects and Factors Affecting Change

Ding¹,

Cicuttini²,

Scott³

et al. 2006

Arch Intern Med

152

162

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Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history.Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later.Results: Thirty-three percent of the subjects had a worsening (Ն1-point increase) and 37% of the subjects had an improvement (Ն1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment).Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.

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Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study

Cited by 69 publications

References 37 publications

Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference

Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Natural History of Knee Cartilage Defects and Factors Affecting Change

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