Measurement and Application of MTF

Hatagawa, Masakatsu

doi:10.6009/jjrt.kj00003325682

Cited by 1 publication

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“… 61 In the absence of serum proteins as the ζ-potential (measure of surface charge) approaches 0, cells find it increasingly hard to attach. 62 Gypsum has a ζ-potential of ∼−15 mV 63 while brushite has −30 to −45 mV at physiological pH, 64 , 65 likely explaining the lack of cells present on the former.…”

Section: Resultsmentioning

confidence: 99%

Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements

Sarrigiannidis

Moussa

Dobre

et al. 2020

ACS Appl. Bio Mater.

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Brushite cements are promising bone regeneration materials with limited biological and mechanical properties. Here, we engineer a mechanically improved brushite–collagen type I cement with enhanced biological properties by use of chiral chemistry; d - and l -tartaric acid were used to limit crystal growth and increase the mechanical properties of brushite–collagen cements. The impact of the chiral molecules on the cements was examined with Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). A 3-point bend test was utilized to study the fracture toughness, and cell attachment and morphology studies were carried out to demonstrate biocompatibility. XRD and SEM analyses showed that l -, but not d -tartaric acid, significantly restrained brushite crystal growth by binding to the {010} plane of the mineral and increased brushite crystal packing and the collagen interaction area. l -Tartaric acid significantly improved fracture toughness compared to traditional brushite by 30%. Collagen significantly enhanced cell morphology and focal adhesion expression on l -tartaric acid-treated brushite cements.

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