Measurement and comparison of skin dose using OneDose MOSFET and Mobile MOSFET for patients with acute lymphoblastic leukemia

Abstract

SummaryBackgroundTotal body irradiation is a protocol used to treat acute lymphoblastic leukemia in patients prior to bone marrow transplant. It is involved in the treatment of the whole body using a large radiation field with extended source-skin distance. Therefore measuring and monitoring the skin dose during the treatment is important. Two kinds of metal oxide semiconductor field effect transistor (OneDose MOSFET and mobile MOSEFT) dosimeter are used during the treatment delivery to measure the skin dose to specific points and compare it with the target prescribed dose.The objective of this study was to compare the variation of skin dose in patients with acute lymphatic leukemia (ALL) treated with total body irradiation (TBI) using OneDose MOSFET detectors and Mobile MOSFET, and then compare both results with the target prescribed dose.Material/MethodsThe measurements involved 32 patient’s (16 males, 16 females), aged between 14–30 years, with an average age of 22.41 years. One-Dose MOSFET and Mobile MOSFET dosimetry were performed at 10 different anatomical sites on every patient.ResultsThe results showed there was no variation between skin dose measured with OneDose MOSFET and Mobile MOSFET in all patients. Furthermore, the results showed for every anatomical site selected there was no significant difference in the dose delivered using either OneDose MOSFET detector or Mobile MOSFET as compared to the prescribed dose.ConclusionsThe study concludes that One-Dose MOSFET detectors and Mobile MOSFET both give a direct read-out immediately after the treatment; therefore both detectors are suitable options when measuring skin dose for total body irradiation treatment.

Surface Radiation Dose Measurement with Mosfet for Head and Neck Cancer using Phantom

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Blocking HIF-1α Following Radiotherapy to Prolong and Enhance the Immune Effects of Radiotherapy: A Hypothesis

“…However, this balance has been proven to be upset by interventions such as radiotherapy that contribute to systemic antitumor immunity [ 7 , 8 ]. Enhanced expression of death receptors, MHC class I molecules, costimulatory molecules, adhesion molecules (ICAM-1 and VCAM-1), and stress-induced ligands on tumor cells after radiation increased their recognition and killing by T cells or NK cells in vitro and/or in vivo in several cancer models [ 9 ].…”

Gene polymorphisms of ABC transporters are associated with clinical outcomes in children with acute lymphoblastic leukemia

“…Current therapeutic options include the use of 1) thiopurine antimetabolites such as mercaptopurine (MP) and thioguanine (TG); 2) high dose methotrexate (HDMTX) given as consolidation therapy and low dose methotrexate (LDMTX) given as continuation therapy; 3) synthetic glucocorticoids such as dexamethasone and prednisolone, which induce G1 cell cycle arrest and apoptosis, and 4) L-asparaginase [ 9 ]. Pediatric ALL patients are also subjected to total body irradiation prior to bone marrow transplant [ 10 , 11 ].…”