Measurement and Correlation of l-Phenylalanine Benzyl Ester Hydrochloride Solubility in 11 Individual Solvents and a Methanol + Acetone Binary Solvent System from 283.15 to 323.15 K

Abstract

The mole fraction solubility data of L-phenylalanine benzyl ester hydrochloride in 11 neat solvents including, methanol, ethanol, n-propanol, n-butanol, n-pentanol, i-butanol, i-propanol, water, acetone, acetonitrile, and ethyl acetate, as well as one binary mixed solvent of methanol + acetone were measured using the static gravimetric method at a temperature interval of "T = 283.15−323.15 K" and a pressure of "p = 98.8 kPa". The powder X-ray diffraction test was employed to identify the solid-phase characterization of Lphenylalanine benzyl ester hydrochloride in the investigated solvent systems. At constant solvent composition, the solubility was positively correlated with temperature. In the selected monosolvents, the solubility of L-phenylalanine benzyl ester hydrochloride was restricted by multiple factors, and the following order was obtained: methanol > ethanol > n-propanol > n-butanol > n-pentanol > i-butanol > i-propanol > acetone > acetonitrile > ethyl acetate (except for water, which intersects with other solvents). In addition, the modified Apelblat model and the Apelblat−Jouyban−Acree model were employed to fit the solubility data.

Solubility Measurement of the Crystal Form 1 and Form 4 Nirmatrelvir in Six Mono-Solvents and Two Binary Solvent Mixtures

“…The solution might have hydrogen bonding interactions between solute molecules and solvent molecules. In a word, the solubility resulted from the several different properties of solvents …”

“…In a word, the solubility resulted from the several different properties of solvents. 24 5.1.2. Solubility Data in the Binary Solvent Mixture.…”

Determination of L-Glutamine Solubility in 12 Pure Solvent Systems from 283.15 to 323.15 K

“…The static gravimetric method was used to determine the molar solubility of L -glutamine in selected 12 monosolvents. − To ensure accuracy, each experiment was performed at least three times. The procedure and equipment for this experiment are described in detail in the Supporting Information and have been verified in our previous studies. − The mole fraction solubility of L -glutamine ( x 1 ) can be determined by eq : x 1 = m 1 / M 1 m 1 / M 1 + m 2 / M 2 …”

Study on vapor–liquid equilibrium and microscopic properties of DL-proline, L-glutamic acid, and L-serine aqueous solutions

“…It is very significant to study the properties of amino acids, while solubility is an important physicochemical property that determines the phase equilibrium ( Do et al, 2021 ; Sadeghi et al, 2021 ). Phase equilibrium has been widely used as the theoretical basis for the separation and purification of inorganic salts, organic molecules, and biological macromolecules in the chemical industry ( Vartak et al, 2018 ; Zhu et al, 2020 ; Huang et al, 2021 ). In recent years, research on phase equilibrium has mainly focused on single electrolyte solution systems and mixed electrolyte solutions systems ( Huang et al, 2021 ; Xu et al, 2019 ; Cui et al, 2021 ).…”

“…Phase equilibrium has been widely used as the theoretical basis for the separation and purification of inorganic salts, organic molecules, and biological macromolecules in the chemical industry ( Vartak et al, 2018 ; Zhu et al, 2020 ; Huang et al, 2021 ). In recent years, research on phase equilibrium has mainly focused on single electrolyte solution systems and mixed electrolyte solutions systems ( Huang et al, 2021 ; Xu et al, 2019 ; Cui et al, 2021 ). The relationship between temperature, solubility, and saturated vapor pressure of a single solute in different solvents was studied ( Xu et al, 2018 ).…”