Measurement and Correlation of α-Bisabolol Solubility in Near-Critical Carbon Dioxide

Abstract

The solubility of (−)-α-bisabolol, ((−)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol), a monocyclic sesquiterpene alcohol, in sub-and supercritical CO 2 was measured at the temperatures (313.2, 323.2, and 333.2) K and pressures ranging from (7 to 12.5) MPa by a dynamic method. To the best of our knowledge, there are no previous measurements of α-bisabolol solubility in near critical CO 2 reported in the literature. The solubility isotherms were in the crossover region; the maximum mole fraction of α-bisabolol in CO 2 , 9•10 −3 , was therefore at 313.2 K and 11.5 MPa, the maximum pressure applied at this temperature. The Soave−Redlich−Kwong equation of state (SRK-EoS) was employed to correlate the experimental data and an acceptable agreement was obtained. Furthermore, the thermophysical properties of the solute required by the modeling were estimated and reported.

Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli

“…Interestingly, no statistically significant differences were observed in the production of HE by the addition of (+)‐ epi ‐α‐bisabolol in the range of 120–210 mg L −1 . This fact should be associated with the low solubility of (+)‐ epi ‐α‐bisabolol in polar solvents [17] . Considering that (+)‐ epi ‐α‐bisabolol is an immedate precursor of HE, these results endorse the conversion of this oxygenated sesquiterpenoid into HE in P. scaberrima .…”