Measurement and cytologic demonstration of 5‐S‐cysteinyldopa for the clinical diagnosis of primary leptomeningeal melanoma

Kamei, Satoshi; Morishima, Takafumi; Mizutani, T.; Takasu, Toshiaki; Ochiai, T.; Kamei, M.; Nemoto, Norimichi; Nakayama, T

doi:10.1212/wnl.44.1.175

Cited by 3 publications

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“…The diagnosis of HSV is currently made by the PCR technique that demonstrates the presence of viral DNA in the CSF. After appropriate treatment the viral load decreases and the PCR became negative and thus, it may be useful to evaluate efficacy of treatment [2,8] .…”

Section: Discussionmentioning

confidence: 99%

Hepatitis, Meningitis and Hydrocephalus Caused by Herpes Simplex Virus Type I

Pina¹,

Modrego²,

Galve³

2006

American J. of Infectious Diseases

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Herpes simplex virus type is the most frequent cause of sporadic and severe encephalitis in western countries. We report the exceptional case of an immunocompetent man aged 51 and who presented with hepatitis and meningitis by herpes simplex virus. Encephalitis responded to acyclovir but hepatitis did not. The patient developed diffuse hydrocephalus that required the appropriate shunt 20 days after being asymptomatic. Several aspects deserve discussion: the clinical onset with meningeal syndrome, the value of the PCR technique for diagnosis and follow-up purposes, the magnetic resonance (MRI) findings, the anicteric hepatitis with reversible cytolysis and persistent coagulation deficit and the hydrocephalus that was due not to direct effect of the virus but to a probable immunological mechanism.

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Section: Discussionmentioning

confidence: 99%