Measurement and Thermodynamic Modeling of the Solubility of Lamotrigine, Deferiprone, Cefixime Trihydrate, and Cephalexin Monohydrate in Different Pure Solvents from 283.1 to 323.1 K

Abstract

The solubility of lamotrigine, deferiprone, cefixime trihydrate, and cephalexin monohydrate (pharmaceutical solutes) were measured in water, methanol, acetonitrile, and ethyl acetate from 283.1 to 323.1 K at atmospheric pressure. Cephalexin monohydrate was unstable and decomposed in ethyl acetate (even at 283.1 K), acetonitrile (at 303.1 K), and methanol (at 313.1 K). The experimental solubility data were correlated using the local composition models such as Wilson, nonrandom two-liquid theory (NRTL), universal quasichemical (UNIQUAC), and segment-based UNIQUAC (UNIQUAC-SAC). Moreover, the two temperature-dependent Buchowski-Ksiazaczak λh and modified Apelblat equations were applied to correlate the present data. The predicted solubility of the present studies using UNIQUAC-SAC model are compared with those have been given for the other solvents, so that one can conclude lamotrigine, deferiprone, cefixime trihydrate, and cephalexin monohydrate presented the highest solubility in acetic acid, acetic acid, formic acid, and acetic acid, respectively.

Thermodynamic Modeling and Solubility Measurement of Cetirizine Hydrochloride and Deferiprone in Pure Solvents of Acetonitrile, Ethanol, Acetic Acid, Sulfolane, and Ethyl Acetate and Their Mixtures

“…Present experimental solubility of benzoic acid in water versus temperature and comparison with those reported in the literature. Wang et al (●), Strong et al (●), Kong et al (●), Apelblat et al (●), Yousefi Seyf and Haghtalab (●), Oliveira et al (●), and the present study (■).…”

“…In this work, the solubility of CTZ in four pure mentioned solvents and their binary mixtures was measured at temperatures ranging from 283.15 to 323.15 K at atmospheric pressure by using double-beam spectrophotometers model T80 + UV/visible (vis) spectrometer. Moreover, the solubility of deferiprone in ethyl acetate and acetonitrile has already been reported by Haghtalab and Yousefi Seyf . In this study, we measured the solubility of deferiprone in mixtures of ethanol–ethyl acetate and ethanol–acetonitrile at different temperatures and mole fractions of the solvents.…”

“…Moreover, one can see the experimental solubility of deferiprone in the same monosolvents by Fathi-Azarbayjani et al and Jouyban et al using the flask-shake method through UV spectroscopic measurements. Besides, the experimental solubility of deferiprone in ethyl acetate and acetonitrile was measured by Yousefi Seyf and Haghtalab, and their results are compared to those of the present study as shown in Table . As is seen, in spite of the almost same measurement procedures, there are some differences and close agreement among the present measurements and the literature data.…”

Measurement and Thermodynamic Modeling of Lamotrigine Solubility in the Presence of Some Choline-Based Ionic Liquids

“…Also, the real solubility ( x 1 ) is obtained by the combination of the nonideality term, (log γ 1 ), with eq for determination using eq : γ 1 represents the solid activity coefficient which should be obtained experimentally using solubility measurements for experimental systems. Nevertheless, to obtain reasonable estimates of this term, several theoretical techniques have been developed . One method is to use the activity coefficient models summarized below, which are related to the two models used in this study.…”

Advanced Materials for Immunosensing of Pharmaceutical and Drug Compounds

“…To date, wide vast types of analytical techniques such as high performance liquid-chromatography (HPLC), 1 gas chromatography (GC), 2 electrochemical, [3][4][5][6] luminescence, [7][8][9][10][11] etc. have been used for the determination of pharmaceuticals in different biological and environmental media.…”