Measurement of 2-nonenal and diacetyl emanating from human skin surface employing passive flux sampler—GCMS system

Kimura, Koichiro; Sekine, Yoshika; Furukawa, Shota; Takahashi, M; Oikawa, Daisuke

doi:10.1016/j.jchromb.2016.06.021

Cited by 33 publications

(28 citation statements)

References 15 publications

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“…Due to their ease-of-use feature these devices can be adapted for sampling from various parts of the body and track metabolic changes associated with particular conditions. For example, a recent study by Kimura et al investigated the causes of the characteristic "elderly body odor" by sampling from different areas of the skin from participants in three different age groups (young-, middle-and old-aged) using a passive sampling device [73]. MonoTrap ® DCC18 containing octadecylsilane functionalized monolithic silicate and activated carbon as extractive media providing with a large surface area and high trapping capacity (O.D.…”

Section: Passive Flux Samplersmentioning

confidence: 99%

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Advancements in Non-Invasive Biological Surface Sampling and Emerging Applications

Nalbant

Boyacı

2019

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Biological surfaces such as skin and ocular surface provide a plethora of information about the underlying biological activity of living organisms. However, they pose unique problems arising from their innate complexity, constant exposure of the surface to the surrounding elements, and the general requirement of any sampling method to be as minimally invasive as possible. Therefore, it is challenging but also rewarding to develop novel analytical tools that are suitable for in vivo and in situ sampling from biological surfaces. In this context, wearable extraction devices including passive samplers, extractive patches, and different microextraction technologies come forward as versatile, low-invasive, fast, and reliable sampling and sample preparation tools that are applicable for in vivo and in situ sampling. This review aims to address recent developments in non-invasive in vivo and in situ sampling methods from biological surfaces that introduce new ways and improve upon existing ones. Directions for the development of future technology and potential areas of applications such as clinical, bioanalytical, and doping analyses will also be discussed. These advancements include various types of passive samplers, hydrogels, and polydimethylsiloxane (PDMS) patches/microarrays, and other wearable extraction devices used mainly in skin sampling, among other novel techniques developed for ocular surface and oral tissue/fluid sampling.

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Section: Passive Flux Samplersmentioning

confidence: 99%

“…The PFS (passive flux sampler) was fixed by a piece of medical tape. Reproduced from[63,73], with permission from Wiley and Elsevier, 2019.…”

mentioning

confidence: 99%

Advancements in Non-Invasive Biological Surface Sampling and Emerging Applications

Nalbant

Boyacı

2019

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“…This study aimed to characterize the mechanism of toluene emanating from the skin surface of healthy volunteers and to identify the influence of being exposed to toluene in an indoor environment on the dermal emission employing a passive flux sampler (PFS) coupled and gas chromatography-mass spectrometry (GC-MS) (2,3,6). The PFS is a simple device developed by the authors to determine the dermal emission flux (emission rate per area) of Copyright © 2019, Journal of Skin and Stem Cell.…”

Section: Objectivesmentioning

confidence: 99%

“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. volatile organic compounds (VOCs) (2,3,6). The sampler can be used anywhere non-invasively and be operated by non-medical professionals.…”

Section: Objectivesmentioning

confidence: 99%

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Measurement of Toluene Emanating from the Surface of Human Skin in Relation to Toluene Inhalation

et al. 2019

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Background: Human skin gas is known as traces of gas emanating from the human skin. Exogenous chemicals such as toluene may be released from the skin surface when absorbed into the body. However, dermal emission of toluene has not been fully determined in relation to inhalation exposure. Objectives: This study aimed to characterise the mechanism of toluene emanating from the skin surface of healthy volunteers in relation to inhalation exposure. Methods: Dermal emission flux of toluene was determined in healthy volunteers employing a passive flux sampler and gas chromatography-mass spectrometry. Results: The dermal emission of toluene occurs when toluene is absorbed by inhalation. The half-life obtained from the decrease in the dermal emission flux suggested the time-course of the dermal emission corresponds to that of the blood concentration. The whole-body emission rate of toluene was estimated to be 9.9% of the uptake rate by inhalation exposure. This suggests the toluene is excreted approximately 80% through urine, 7%-14% by exhaled air, and 10% from the skin surface. Conclusions: This demonstrates that dermal emission is a newly discovered route of excretion of toluene from the human body and that dermal toluene might indicate the individual biological susceptibility to inhalation exposure to toluene.

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Sensory evaluation of axillary odour samples of younger and older adults by a trained panel

Owsienko,

Schwinn,

Eskofier

et al. 2023

Flavour & Fragrance J

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It has been reported that a distinct ‘old person smell’ can develop with advancing age, however, this odour has not yet been sufficiently described in previous research. Sensory evaluation by a trained panel might be useful to describe alterations with age in body odour (BO). To evaluate the alterations and achieve first insights into the ‘old person smell’, this pilot study determined the odour profiles of BO samples from both a younger and an older age group with a trained panel. In addition, we aimed to assess whether the panellists can recognize the age group based on the smell of the BO samples. Eight younger (20–28 years) and eight older (80–83 years) participants sampled their BO by wearing a cotton T‐shirt for one night. The samples were sensorially evaluated by a trained panel, including ratings of total intensity and pleasantness. Additionally, an age labelling task was performed as a forced‐choice decision. Results revealed that the odour profiles of the BO samples were very similar for both age groups. Nevertheless, trained panellists were able to predict the age group with significantly higher accuracy (p = .042) than expected by chance (61% mean accuracy over all panellists). Furthermore, a linear support vector machine (SVM) classifier achieved an average accuracy of 69%. This finding indicates that the age of a person affects the BO, though it is not reflected in significantly distinct odour profiles.

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Measurement of 2-nonenal and diacetyl emanating from human skin surface employing passive flux sampler—GCMS system

Cited by 33 publications

References 15 publications

Advancements in Non-Invasive Biological Surface Sampling and Emerging Applications

Advancements in Non-Invasive Biological Surface Sampling and Emerging Applications

Measurement of Toluene Emanating from the Surface of Human Skin in Relation to Toluene Inhalation

Sensory evaluation of axillary odour samples of younger and older adults by a trained panel

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