Measurement of 5-methoxypsoralen and 8-methoxypsoralen in saliva of PUVA patients as a noninvasive, clinically relevant alternative to monitoring in blood

Abstract

Monitoring of psoralens in saliva is a valuable, noninvasive alternative to measurements in serum, suitable for routine use. A series of five or six saliva samples is sufficient to determine tmax in a patient beginning photochemotherapy. To determine Cmax, three independent saliva measurements at t = tmax are recommended.

Interindividual differences in phytochemical metabolism and disposition

“…Circulating concentrations of phytochemicals, such as psoralens, lignans, and the flavonoids naringenin and hesperitin, can vary widely among individuals even in the context of controlled feeding studies [8][9][10]. The process of phytochemical disposition, like that of disposition of drugs and other xenobiotics, involves absorption, metabolism, distribution, and excretion, and each of these parts may contribute to pharmacokinetic variability (Figure 1) [11].…”

Pharmacokinetic behaviour of sublingually administered 8‐methoxypsoralen for PUVA therapy

“…dissolved in isotonic saline solution (50) each individual patient and adjusting the 8-MOP dose and timing of the UVA dose accordingly. Improved therapeutic efficiencies have been reported (7,8), but not every centre has access to the necessary analytical laboratory apparatus or has room to carry out MPD measurements.…”

Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3′-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen

“…Previous research of 8-MOP and 5-MOP has focused on pharmaceutical treatment with psoralen for cutaneous T-cell lymphoma, vitiligo, and psoriasis, resulting in peak serum concentrations of 8-MOP and 5-MOP several hundred times greater than the amounts detected in the contaminated H. pomatia enzymes (Shephard et al, 1999). However, the urinary concentrations of 8-MOP and 5-MOP from apiaceous vegetable consumption are much lower than those from pharmacological therapy, increasing the likelihood of inaccurate results and misclassification bias from the use of a contaminated enzyme.…”