Measurement of 75Se-SeHCAT Abdominal Retention in the Initial Diagnosis of Bile Acid Absorption (BAM)

Notta, P.; Ramal, D.; Maisterra, Sandra; Gasen, A. Rodríguez; Maymó, Sílvia; Sabaté, Antoni; Girbau, Anna; Guardiola, Jordi; Martín-Comín, J.

doi:10.1016/j.remngl.2011.03.005

Revista Española de Medicina Nuclear (English Edition)

2011

DOI: 10.1016/j.remngl.2011.03.005

|View full text |Cite

Measurement of 75Se-SeHCAT Abdominal Retention in the Initial Diagnosis of Bile Acid Absorption (BAM)

P. Notta

D. Ramal

Sandra Maisterra

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2012

2018

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we have started to apply the test, using the collimated gamma camera, in the early stages and we have published our results in the Revista Española de Medicina Nuclear [5]. We have observed that the prevalence of bile acid malabsorption in patients with chronic diarrhea is about 43% and the response rate of these patients to therapy with bile acid-chelating agents is over 95%.…”

mentioning

confidence: 98%

“…The results were excellent and we published the method in a letter to the editor in the European Journal of Nuclear Medicine [2] and our results in the Revista Española de Medicina Nuclear [3]. We have continued the use of this methodology for 20 years, with excellent collaboration and agreement between gastroenterologists and nuclear medicine doctors.Unfortunately, during this entire period, the test has been performed in advanced stages of chronic diarrhea, as stated in usual protocols [4].Recently, we have started to apply the test, using the collimated gamma camera, in the early stages and we have published our results in the Revista Española de Medicina Nuclear [5]. We have observed that the prevalence of bile acid malabsorption in patients with chronic diarrhea is about 43% and the response rate of these patients to therapy with bile acid-chelating agents is over 95%.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Influence of 99Tc in the preparation of 99mTc radiopharmaceuticals

Urbano

Modoni

2012

Nuclear Medicine Communications

View full text Add to dashboard Cite

We have read with interest the technical note from Notghi et al.[1] on the renewed interest of the 75 Se-HCAT test in the evaluation of bile acid malabsorption.We agree on the general presentation of the technical note. However, the authors do not make any comment about the possibility of the use of a collimated gamma camera.As the authors mention, the first experiences with 75 Se-HCAT were assessed using a whole-body counter. The difficulties and limited availability limited the widespread use of the method.The method described by the author, the use of an uncollimated gamma camera, simulates a whole-body counter. Nevertheless, the use of an uncollimated gamma camera requires accurate control of background activity (patients, activity transport, contamination, etc.) in the nuclear medicine department as well as in the examination room. Patients being examined at the same time in the department may alter the measurement of the background activity.As bile acid absorption is mostly limited to the terminal ileum and the enterohepatic circuit is localized in the abdomen, the 75 Se activity outside of the abdomen is negligible. Thus, the measurement of abdominal 75 Se activity should be almost the same as the measurement of whole-body activity, especially with the 'new' large fieldof-view gamma cameras.On the basis of these assumptions, in the late 1980s, we began to perform the test using a collimated gamma camera. The results were excellent and we published the method in a letter to the editor in the European Journal of Nuclear Medicine [2] and our results in the Revista Española de Medicina Nuclear [3]. We have continued the use of this methodology for 20 years, with excellent collaboration and agreement between gastroenterologists and nuclear medicine doctors.Unfortunately, during this entire period, the test has been performed in advanced stages of chronic diarrhea, as stated in usual protocols [4].Recently, we have started to apply the test, using the collimated gamma camera, in the early stages and we have published our results in the Revista Española de Medicina Nuclear [5]. We have observed that the prevalence of bile acid malabsorption in patients with chronic diarrhea is about 43% and the response rate of these patients to therapy with bile acid-chelating agents is over 95%.The use of a collimated gamma camera allows patient examinations to be scheduled at any working time. As there is no interference due to patients present in the department, only the room contamination by other causes needs to be controlled. The clinical results we have obtained are excellent. In fact, now, our gastroenterologist prescribes the test as the first line of diagnosis.

show abstract

mentioning

confidence: 98%

mentioning

confidence: 99%

Influence of 99Tc in the preparation of 99mTc radiopharmaceuticals

Urbano

Modoni

2012

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Fani

Bertani

Paglianiti

et al. 2018

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. The SeHCAT test provides a quantitative assessment to estimate the severity of BAM and the possible response to therapy with bile acid sequestrants (BASs). However, there is no general agreement regarding its cutoff value and the test is not widely available. The aim of this review is to discuss the advantages and disadvantages of the SeHCAT test in clinical practice.

show abstract

SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis

Riemsma

Al²,

Ramos³

et al. 2013

Health Technology Assessment

View full text Add to dashboard Cite

, et al. acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis. Health Technol Assess 2013;17(61). This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/). Health Technology Assessment is indexed and abstracted inEditorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.ukCriteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was commissioned and funded by the HTA programme on behalf of NICE as project number 11/75/01. The protocol was agreed in December 2011. The assessment report began editorial review in May 2012 and was accepted for publication in November 2012. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included...

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Measurement of 75Se-SeHCAT Abdominal Retention in the Initial Diagnosis of Bile Acid Absorption (BAM)

Cited by 3 publications

References 15 publications

Influence of 99Tc in the preparation of 99mTc radiopharmaceuticals

Influence of 99Tc in the preparation of 99mTc radiopharmaceuticals

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis

Contact Info

Product

Resources

About