Measurement of Antidepressants Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective Detection

Rifai, Nader; Howlett, Cheryl M.; Levtzow, Cyndy B.; Phillips, Julius C.; Parker, Nancy C.; Cross, Robert E.

doi:10.1097/00007691-198802000-00014

Therapeutic Drug Monitoring

1988

DOI: 10.1097/00007691-198802000-00014

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Measurement of Antidepressants Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective Detection

Nader Rifai¹,

Cheryl M. Howlett²,

Cyndy B. Levtzow³

et al.

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1992

2008

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Cited by 11 publications

References 8 publications

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UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms

Vujić¹,

Radulovic²,

Lučić³

et al. 2003

Chromatographia

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Maprotiline, desTpramTne and moclobemTde are widely used Tn the treatment of depressTon. The content of these antidepressants in bulk drug and pharmaceutical formulations were de termined by ILC and in situ densitometry using a Camag scanner. In order to achieve the best condition, mathematical statistical model factorial design was chosen. The partition coeffi dents, calculated by applyng commercal drug design software, were correlated wth chroma tographic behaviour of these substances. After separation on Silica gel GF254 using propanol ethanol-ammonium solutTon (25%) (8:2:0.3 v/v/v) as the mobTle phase, the chromatographic zones correspondTng to the spots were scanned at 254 nm. AnalysTng Maprotilin | tablets, Pertartan | dragees and Auromid | film tablets examined the app licobTITiy of the method forsampies and dosage forms.

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UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms

Vujić¹,

Radulovic²,

Lučić³

et al. 2003

Chromatographia

View full text Add to dashboard Cite

show abstract

Statistical Optimization Applied to Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Capillary Zone Electrophoresis

Vujić¹,

Kuntić

Ivković³

2008

Monatsh Chem

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High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent

François

Ardid

Eschalier

et al. 1992

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Measurement of Antidepressants Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective Detection

Cited by 11 publications

References 8 publications

UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms

UV-densitometric determination of maprotiline, desipramine and moclobemide in pharmaceutical dosage forms

Statistical Optimization Applied to Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Capillary Zone Electrophoresis

High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent

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