Measurement of Antiplatelet Inhibition during Neurointerventional Procedures: The Effect of Antithrombotic Duration and Loading Dose

Abstract

Premedication with clopidogrel, in contrast to aspirin, does not achieve adequate platelet inhibition in about two-third of the patients. Same day antiplatelet loading may be insufficient to achieve adequate platelet inhibition and should be avoided if clinically feasible.

Microembolic Signal Monitoring after Coiling of Unruptured Cerebral Aneurysms: An Observational Analysis of 123 Cases

“…The efficacy of antiaggregational medication such as aspirin and clopidogrel is known to vary depending on the patient's drug susceptibility, as well as the dose and time of application. 7 Despite various treatment and prophylaxis algorithms, the rate of thromboembolic events remains high, suggesting that not only an improvement in technique and development of new embolic materials but also an optimization of drug intervention and monitoring is mandatory.…”

Association betweenCYP2C19Polymorphisms and Outcomes in Cerebral Endovascular Therapy

“…Up to 66% of patients with cerebrovascular disease have a reduced response to clopidogrel, [8][9][10][11] placing them at higher risk of thrombosis, 12 while 14.9%-38% of patients are hyper-responsive to clopidogrel. 13,14 Differing responses to clopidogrel may be related to CYP2C19 gene polymorphisms.…”

Stent-Assisted Techniques for Intracranial Aneurysms

“…Four case series were published in 2008 , MullerSchunk et al, 2008, Pandya et al, 2008, Prabhakaran et al, 2008. Only two have studied the incidence of thromboembolism using techniques and different cut-offs.…”