Measurement of Aqueous Humor Flow Following Scierai Injection of Sulfacetamide as Marker: Effect of Methazolamide, Timolol, and Pilocarpine

Vogh, Betty P.; Godman, David R.; Maren, Thomas H.

doi:10.1089/jop.1989.5.293

Cited by 7 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One should also note that the methods used to measure the rate of so called "aqueous humor production" do not actually measure the production of aqueous humor into the posterior chamber, but instead measure the exit of aqueous humor from the anterior chamber (Lee and Brubaker, 1982;Topper et al, 1984;Vogh et al, 1989), which may include a contributing flow of fluid from the iris into the anterior chamber.…”

Section: Fluid and Electrolyte Transport Studies On Isolated Ciliary mentioning

confidence: 99%

Fluid transport phenomena in ocular epithelia

Candia

Alvarez

2008

Progress in Retinal and Eye Research

View full text Add to dashboard Cite

This article discusses three largely unrecognized aspects related to fluid movement in ocular tissues; namely, a) the dynamic changes in water permeability observed in corneal and conjunctival epithelia under anisotonic conditions; b) the indications that the fluid transport rate exhibited by the ciliary epithelium is insufficient to explain aqueous humor production; and c) the evidence for fluid movement into and out of the lens during accommodation. We have studied each of these subjects in recent years and present an evaluation of our data within the context of the results of others who have also worked on electrolyte and fluid transport in ocular tissues. We propose that 1) the corneal and conjunctival epithelia, with apical aspects naturally exposed to variable tonicities, are capable of regulating their water permeabilities as part of the cell-volume regulatory process, 2) fluid may directly enter the anterior chamber of the eye across the anterior surface of the iris, thereby representing an additional entry pathway for aqueous humor production, and 3) changes in lens volume occur during accommodation, and such changes are best explained by a net influx and efflux of fluid.

show abstract

Section: Fluid and Electrolyte Transport Studies On Isolated Ciliary mentioning

confidence: 99%

Fluid transport phenomena in ocular epithelia

Candia

Alvarez

2008

Progress in Retinal and Eye Research

View full text Add to dashboard Cite

show abstract

“…Timolol maleate is a β-adrenergic receptor antagonist that reduces IOP by decreasing production of aqueous humor. 5,6 It is a safe and effective drug for the treatment of glaucoma in humans and for a number of years was typically regarded as the drug of choice in the treatment of primary open-angle glaucoma in humans. However, efficacy for the commercially available concentration of timolol (0.5%) in domestic animals is not clear.…”

mentioning

confidence: 99%

Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs

Smith

Miller²,

Felchle³

2010

ajvr

View full text Add to dashboard Cite

show abstract

“…SCT is in its anion form at pH 12.5 based on its dissociation constant (pK a1 = 1.8, and pK a2 = 5.4) (Figure S1). 31 In the UV/ketone/alcohol system (unbuffered), we measured the pH before and after each experiment, and no change in pH was observed.…”

Section: Reactivity Of Omentioning

confidence: 99%

Reevaluation of the Reactivity of Superoxide Radicals with a Sulfonamide Antibiotic, Sulfacetamide: An Experimental and Theoretical Study

et al. 2021

View full text Add to dashboard Cite

Superoxide radical (O2 •–) is a ubiquitous reactive oxygen species in sunlit natural waters. Here, we selected sulfacetamide (SCT) as a representative sulfonamide antibiotic to investigate its reactivity with O2 •–, as this reaction was reported to be fast with the rate constant k of 7.0 × 107 M–1 s–1. The degradation kinetics of SCT were first studied in the classic McDowell systems (i.e., ultraviolet, acetone, and alcohols) for optimal O2 •– productivity. Comparison of the apparent first-order degradation rates (k app) revealed that 70 mM acetone and 1 M isopropanol were optimal for k app, but it was only ∼10% faster than the control. The small degree of enhancement of k app led us to suspect its high reported reactivity with O2 •–. Therefore, we reevaluated this reaction in organic and aqueous solutions by a suite of spectroscopic techniques, and all evidence indicated that the measured k values were 6 orders of magnitude smaller than the reported one. The low reactivity was also confirmed by theoretical calculations at the M06-2X level of theory. Our results are of practical and scientific importance for the holistic assessment of the role of O2 •– in remediation and attenuation of organic contaminants in natural and engineered waters.

show abstract

Measurement of Aqueous Humor Flow Following Scierai Injection of Sulfacetamide as Marker: Effect of Methazolamide, Timolol, and Pilocarpine

Cited by 7 publications

References 3 publications

Fluid transport phenomena in ocular epithelia

Fluid transport phenomena in ocular epithelia

Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs

Reevaluation of the Reactivity of Superoxide Radicals with a Sulfonamide Antibiotic, Sulfacetamide: An Experimental and Theoretical Study

Contact Info

Product

Resources

About