Measurement of Blood Flow Velocity in the Middle Cerebral Artery During Spontaneous Migraine Attacks: A Systematic Review

Shayestagul, Nisar A.; Christensen, Casper Emil; Amin, Faisal Mohammad; Ashina, Sait; Ashina, Messoud

doi:10.1111/head.13106

Cited by 26 publications

(24 citation statements)

References 26 publications

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“…Also, after the intervention, the prothrombin time and activated partial thrombin time was increased, the fibrinogen content and the expression of TXB2 and 6-Keto-PGF1α were decreased. This is consistent with the results of blood flow changes during migraine attacks (Shayestagul et al, 2017). This shows that astragalus polysaccharide can improve the hemorheology and coagulation function of rat cerebral thrombosis model, and has a certain inhibitory effect on the formation and development of cerebral thrombosis.…”

Section: Discussionsupporting

confidence: 91%

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats

Sun

Shi

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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ObjectiveTo investigate the efficacy and improvement of Astragalus polysaccharides (APS) and APS-nano on cerebral thrombosis in rats.MethodsA total of 72 SD rats were randomly divided into NC group, Model group, APS-Nano group, and APS group. The cerebral thrombosis Model of SD rats was established by injecting compound thrombus inducer into the internal carotid artery. After 14 days of different intervention treatments, the TTC staining of brain tissue were performed, and A/left brain wet weight ratio, left brain/right brain wet weight ratio, blood rheology indexes, and coagulation function indexes of cerebral thrombosis were measured. ELISA was used to measure the contents of thromboxane 2 (TXB2), 6-keto-prostaglandin F1α (6-Keto-PGF1α), tissue factor (TF), neuron-specific enolase (NSE), S-100β, catenin (CAT), superoxide dismutase (SOD), as well as malondialdehyde (MDA). The binding specificity between miR-885-3p and TF was verified by the double-luciferin reporting experiment, and western blot was used to measure the expression level of TF protein.ResultsCompared with the Model group, after treatment with APS-nano or APS, the ratio of left brain/right brain wet weight decreased significantly. Whole blood low shear viscosity (WBLSV), whole blood high shear viscosity (WBHSV), plasma viscosity (PV), and erythrocyte aggregation index (Arbc) was all reduced. In addition, prothrombin time (PT) and activated partial thromboplastin time (APTT) were increased, and fibrinogen (FIB) content was decreased. The expression of TXB2, 6-Keto-PGF1α, and TF showed a downward trend. Similarly, the expression of TF protein was decreased. Furthermore, the contents of NSE and S-100β proteins were all decreased, whereas the contents of CAT and SOD were increased, and the contents of MDA was decreased. At the same dose, compared with APS treatment, APS-nano treatment had a significant inhibitory effect on cerebral thrombosis in rats. Finally, we found that TF is a target gene of miR-885-3p and specifically binds to miR-885-3p.ConclusionAPS has a significant inhibitory effect on the formation of cerebral thrombosis induced by compound thrombus inducers. Moreover, APS-nano has a more significant inhibitory effect on cerebral thrombosis. Meanwhile, the regulation of miR-885-3p regulating TF expression may be related to the occurrence of cerebral thrombosis.

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Section: Discussionsupporting

confidence: 91%

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats

Sun

Shi

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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“…During a migraine attack, sensitization of the trigeminal vascular system (TGVS), including the network of intra- and extracranial meningeal blood vessels and ocular structures, affecting the vascular tone and the transmission of pain signals, is observed [ 17 , 18 , 19 ]. The hypo-perfusion of the eyes’ structures occurring during a migraine attack (due to cerebral vessels vasoconstrictions) and repetitive attacks can lead to permanent damage of the brain and eye structures, including retina [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study

et al. 2020

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Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p < 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p = 0.014 for the right eye and p = 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation.

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“…To the best of our knowledge, migraine has never been reported in ATS patients and the present data are not sufficient to conclude if this symptom is a result of the disease per se or has a different pathogenesis. Nevertheless, we can speculate that migraine might be part of the ATS spectrums, as cerebral hypo-perfusion and blood flow velocity changes are mechanisms involved in the pathogenesis of migraine and it is known that the tortuosity of cerebral arteries might lead to the above-mentioned brain blood flow changes [ 11 , 12 ]. The report by Pelaez et al .…”

Section: Discussionmentioning

confidence: 99%

Clinical variability in two Macedonian families with Arterial tortuosity syndrome

Kočova¹,

Kacarska²,

Kuzevska-Maneva³

et al. 2018

Balkan Journal of Medical Genetics

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Arterial tortuosity syndrome (ATS) is a rare autosomal recessive disorder caused by mutations in the solute carrier family 2 member 10 (SLC2A10) gene encoding a glucose/ascorbic acid transporter. The clinical features of ATS are mild-to-severe tortuosity of the large and medium arteries throughout the body, accompanied by dysmorphisms and joint laxity. Vascular changes in different parts of the body lead to stenosis and/or aneurysms requiring difficult surgical procedures. Here we present two new patients with ATS from two unrelated families. Patient 1 presented at 10 years of age with headache and typical physical appearance, delicate skeleton, large visible pulsation of the carotid arteries in the neck, and joint laxity. On computed tomography (CT) angiography she had severe tortuosity of the aortal branches and cerebral arteries, but no significant tortuosity of the pulmonary arteries. Two cousins of the girl carried the same homozygous c.254T>C, p.(Leu85Pro) mutation in SLC2A10, however, they additionally had a severe involvement of the pulmonary vessels. Patient 2 was a 9-year-old girl diagnosed with severe tortuosity and stenosis of the pulmonary arteries and progressive myocardiopathy. Her physical appearance was very similar to Patient 1, except that she also had growth retardation. After long-term follow-up by cardiologists, she underwent cardiac surgery abroad, with an unfavorable outcome. Homozygosity for the c.685C>T, p.(Arg229*) mutation in the SLC2A10 gene was detected. Consanguinity was disclosed within both families. Our findings confirm the intrafamilial phenotype variability of ATS. A novel finding is the severe tortuosity of cerebral arteries causing migraine that has not been described before in a child with ATS.

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Measurement of Blood Flow Velocity in the Middle Cerebral Artery During Spontaneous Migraine Attacks: A Systematic Review

Cited by 26 publications

References 26 publications

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats

Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study

Clinical variability in two Macedonian families with Arterial tortuosity syndrome

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